{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:53:27Z","timestamp":1792572807622,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psychedelic drugs have been of interest in medicine since the early 1950s. There has recently been a resurgence of interest in psychedelics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The objective of this study is to determine the extent of the available literature on psilocybin for medical indications including the designs used, study characteristics, indications studied, doses, and authors\u2019 conclusions. We identify areas for further study where there are research gaps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a systematic scoping review of clinical indications for psilocybin, encompassing psychiatric and medical conditions. We systematically searched Medline and Embase using keywords related to psilocybin. We reviewed titles and texts in duplicate using Covidence software. We extracted data individually in duplicate using Covidence software and a senior reviewer resolved all author conflicts. We analyzed data descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 193 published and 80 ongoing studies. Thirty-seven percent of included studies were systematic reviews. Only 12% of included studies were randomized controlled trials. The median number of participants was 22 with a median of 18 participants who had taken psilocybin. Thirty-eight percent of studies reported at least one potential conflict of interest. The most common indication was depression (28%). Also commonly studied were substance use (14%), mental health in life-threatening illness (9%), headaches (6%), depression and anxiety (6%), obsessive-compulsive disorder (3%), and anxiety disorders (3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Most studies involving the administration of psilocybin have small sample sizes and the most common focus has been psychiatric disorders. There is a need for high-quality randomized trials on psilocybin and to expand consideration to other promising indications, such as chronic pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241269751","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T03:27:58Z","timestamp":1723519678000},"page":"839-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Psilocybin for clinical indications: A scoping review"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-9636","authenticated-orcid":false,"given":"Kim","family":"Madden","sequence":"first","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"},{"name":"Department of Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Health Research Methods, McMaster University, Hamilton, ON, Canada"},{"name":"Michael G. DeGroote Center for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne","family":"Flood","sequence":"additional","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"},{"name":"Department of Health Research Methods, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Young Shing","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ade-Conde","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons of Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Kashir","sequence":"additional","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Mark","sequence":"additional","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"MacKillop","sequence":"additional","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"},{"name":"Michael G. DeGroote Center for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, ON, Canada"},{"name":"Peter Boris Center for Addiction Research, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Health Research Methods, McMaster University, Hamilton, ON, Canada"},{"name":"Michael G. DeGroote Center for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Adili","sequence":"additional","affiliation":[{"name":"Research Institute of St. Joseph\u2019s Healthcare Hamilton, Hamilton, ON, Canada"},{"name":"Department of Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Michael G. DeGroote Center for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"bibr1-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2016.1278228"},{"key":"bibr2-02698811241269751","unstructured":"Health Canada (2022) Notice to stakeholders\u2014Clarification of requirements under the food and drug regulations and the controlled drugs and substances act when conducting clinical research with psilocybin. https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/drug-products\/announcements\/notice-clarification-requirements-conducting-clinical-research-psilocybin.html (accessed 11 January 2022)."},{"key":"bibr3-02698811241269751","unstructured":"Health Canada (2023) Psilocybin and psilocin (Magic mushrooms). https:\/\/www.canada.ca\/en\/health-canada\/services\/substance-use\/controlled-illegal-drugs\/magic-mushrooms.html (accessed 8 February 2023)."},{"key":"bibr4-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1007\/BF02159243"},{"key":"bibr5-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.05.012"},{"key":"bibr6-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1177\/08980101211039086"},{"key":"bibr7-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_478"},{"key":"bibr8-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1080\/1355621021000005937"},{"key":"bibr9-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196002112620606"},{"key":"bibr10-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2022.2066650"},{"key":"bibr11-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-022-01063-5"},{"key":"bibr12-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000759"},{"key":"bibr13-02698811241269751","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.4101"},{"key":"bibr14-02698811241269751","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090331"},{"key":"bibr15-02698811241269751","first-page":"109","volume":"134","author":"Wollmann H","year":"1950","journal-title":"Z Geburtshilfe Gynakol"},{"key":"bibr16-02698811241269751","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11040938"},{"key":"bibr17-02698811241269751","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2021.0209"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811241269751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811241269751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811241269751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:11:48Z","timestamp":1777507908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811241269751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/02698811241269751"],"URL":"https:\/\/doi.org\/10.1177\/02698811241269751","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}