{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:05:44Z","timestamp":1782187544139,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This review addresses the prevalence of hypersexual behavior in Parkinson\u2019s patients and the underlying neurobiological mechanisms, identifying risk and protective factors, comparing incidence among different treatments, and proposing recommendations for management and prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To conduct a review on the relationship between Parkinson\u2019s disease and hypersexual behavior as a result of pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>The search strategy, guided by PRISMA and PICOS criteria, focuses on the correlation between Parkinson\u2019s disease and hypersexual behavior due to pharmacological treatment. Utilizing databases like PubMed and Proquest, studies from the last 10\u2009years in English or Spanish were selected, emphasizing clinical trials with Parkinson\u2019s patients under treatment. Inaccessible, irrelevant, or mixed-sample studies were excluded. The Cochrane Scale assessed the risk of bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 122 records, 103 remained after eliminating duplicates; 48 were reviewed, and ultimately, 6 studies met the inclusion criteria for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Synthesizing the risk and protective factors linked to hypersexual behavior in Parkinson\u2019s patients receiving pharmacological treatment underscores the critical need for early detection and incorporation of these factors into clinical care. The suggested guidelines for managing and preventing hypersexual behavior in these patients carry substantial practical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241277200","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:39:05Z","timestamp":1726472345000},"page":"316-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The relationship between Parkinson\u2019s disease and sexual hyperactivity secondary to drug treatment: A systematic review"],"prefix":"10.1177","volume":"39","author":[{"given":"Ver\u00f3nica","family":"Aparicio-L\u00f3pez","sequence":"first","affiliation":[{"name":"Universidad Internacional de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-6695","authenticated-orcid":false,"given":"Mar\u00eda","family":"Rueda-Extremera","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Education, Universidad a Distancia de Madrid (UDIMA), Collado Villalba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-2257","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cantero-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Education, Universidad a Distancia de Madrid (UDIMA), Collado Villalba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000082"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-2012-012098"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072464"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa181"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12155"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3654"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212922"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-006-0668-0"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114548437"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-020-02167-1"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2012.03.003"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00351"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/538S1a"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106073109"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy298"},{"key":"e_1_3_2_17_1","first-page":"679","article-title":"Parkinson disease","volume":"102","author":"Halli-Tierney AD","year":"2020","unstructured":"Halli-Tierney AD, Luker J, Carroll DG (2020) Parkinson disease. 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