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The amygdala and prefrontal cortex are strongly innervated by serotonergic projections and have been suggested to play an important role in anxiety expression. However, serotonergic function in behaviour and SSRI-mediated neurobiological changes remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To investigate the neural correlates of subchronic antidepressant administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We investigated whether the 2- to 3-week administration of a highly selective SSRI (escitalopram) would alter brain activation on a task robustly shown to recruit the bilateral amygdala and frontal cortices in a large healthy volunteer sample. Participants performed the task during a functional magnetic resonance imaging acquisition before (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200996) and after subchronic escitalopram (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200946, days of administration mean (SD)\u2009=\u200915.7 (2.70)) or placebo (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200940\u2009days of administration mean (SD)\u2009=\u200916.2 (2.90)) self-administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared to placebo, we found an elevation in right amygdala activation to the task after escitalopram administration without significant changes in mood. This effect was not seen in the left amygdala, the dorsomedial region of interest, the subgenual anterior cingulate cortex or the right fusiform area. There were no significant changes in connectivity between the dorsomedial cortex and amygdala or the subgenual anterior cingulate cortex after escitalopram administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      To date, this most highly powered study of subchronic SSRI administration indicates that, contrary to effects often seen in patients with anxiety disorders, subchronic SSRI treatment may\n                      <jats:italic toggle=\"yes\">increase<\/jats:italic>\n                      amygdala activation in healthy controls. This finding highlights important gaps in our understanding of the functional role of serotonin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241286773","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T12:49:44Z","timestamp":1728046184000},"page":"1071-1082","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Amygdala activity after subchronic escitalopram administration in healthy volunteers: A pharmaco-functional magnetic resonance imaging study"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-9102","authenticated-orcid":false,"given":"Paulina B","family":"Lukow","sequence":"first","affiliation":[{"name":"Institute of Cognitive Neuroscience, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Millie","family":"Lowther","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C","family":"Pike","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience, University College London, London, UK"},{"name":"Department of Psychology &amp; 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