{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:37:40Z","timestamp":1785285460676,"version":"3.55.0"},"reference-count":95,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Among the available pharmacological treatments for acute major depressive disorder (MDD), vortioxetine, a serotonin transporter inhibitor (SERT), has been widely used for its multimodal action on serotonin neurotransmission, which produces essential changes also on glutamate, gamma amino butyric acid (GABA), norepinephrine, acetylcholine, and dopamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis aimed to evaluate the acute efficacy of vortioxetine across multiple dosing and to evaluate whether there is a dose\u2013response effect and as well there is a dose\u2013response issue with respect to side effects in acute depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>According to PRISMA guidelines, we systematically searched three major electronic databases (PubMed\/MEDLINE, PsycINFO, and Cochrane Central Register of Controlled Trials) for Randomized Controlled Trial (RCT) studies published between January 2013 and April 2024. Twenty-four studies were included in the review and two meta-analyses were conducted to determine whether the mean Montgomery\u2013Asberg Depression Rating Scale (MADRS) scale values in the placebo groups differ significantly from the mean MADRS scale values in the group receiving vortioxetine 10\u2009mg or vortioxetine 20\u2009mg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Vortioxetine significantly improved acute depression severity, anxiety symptoms, and cognitive function, with high response and remission rates in acute MDD. It was also well tolerated with a relatively low occurrence of severe or serious treatment-emergent adverse events (TEAEs). Observing the results of the meta-analysis, the effect was significant for both vortioxetine 10 and 20\u2009mg, with a greater effect size for vortioxetine 20\u2009mg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vortioxetine should be considered efficacious as a first- and second-line therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241309612","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:31:52Z","timestamp":1738387912000},"page":"92-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The efficacy of vortioxetine in the acute treatment of major depressive disorder: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-871X","authenticated-orcid":false,"given":"Isabella","family":"Berardelli","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Psychology, Department of Neurosciences, Mental Health, and Sensory Organs, Suicide Prevention Center, Sant\u2019Andrea Hospital, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rogante","sequence":"additional","affiliation":[{"name":"Department of Human Neursciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Formica","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Faculty of Medicine and Psychology, Psychiatry Residency Training Program, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Iannazzo","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Faculty of Medicine and Psychology, Psychiatry Residency Training Program, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio Valerio","family":"Mammoliti","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Faculty of Medicine and Psychology, Psychiatry Residency Training Program, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Riccioni","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Faculty of Medicine and Psychology, Psychiatry Residency Training Program, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skender","family":"Veizi","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Faculty of Medicine and Psychology, Psychiatry Residency Training Program, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-2523","authenticated-orcid":false,"given":"Roger S","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-4977","authenticated-orcid":false,"given":"Maurizio","family":"Pompili","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Psychology, Department of Neurosciences, Mental Health, and Sensory Organs, Suicide Prevention Center, Sant\u2019Andrea Hospital, Sapienza University of Rome, Rome, Lazio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"key":"bibr1-02698811241309612","first-page":"185","volume":"21","author":"Adamo D","year":"2020","journal-title":"Pain Med (Malden, Mass.)"},{"key":"bibr2-02698811241309612","unstructured":"American Psychological Association (2015) APA dictionary of psychology. 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