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Understanding of neuropeptides\u2019 role in complex hunger\/satiety mechanisms may allow new prospects for treatment and prevention. Pyroglutamylated arginine-phenylalanine-amide peptides (QRFPs) are thought to enhance feeding following the central administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In our study, QRFP-26 was delivered into the lateral hypothalamic area of male Wistar rats by direct microinjections, as QRFP-26 expressing neurons and binding sights are densely present in this neural structure. The consumption of liquid food was measured over 60-min.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both doses (100 and 200\u2009ng) significantly decreased food intake compared to the control treatment. Neuropeptide Y Y1R\/NPFF (neuropeptide FF) antagonist BIBP3226 eliminated the anorexigenic effect caused by QRFP-26 administration. QRFP-26 affects neither general locomotion, behavioral patterns examined in the Open Field Test, nor anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study is the first to report the anorexigenic action of QRFP-26 following direct administration into the hypothalamus, emphasizing steady locomotion and anxiety levels. We have shown that the effect of QRFP can be linked to the neuropeptide Y (NPY) Y1 or NPFF receptors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241311454","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T07:26:43Z","timestamp":1738999603000},"page":"254-264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A single injection of neuropeptide QRFP in the lateral hypothalamus decreased food intake"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5038-0753","authenticated-orcid":false,"given":"Olga","family":"Zagor\u00e1cz","sequence":"first","affiliation":[{"name":"Institute of Physiology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Ollmann","sequence":"additional","affiliation":[{"name":"Institute of 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