{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:32:56Z","timestamp":1777858376491,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST110-2314-B-038-072-MY3"],"award-info":[{"award-number":["MOST110-2314-B-038-072-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST111-2320-B-038-044"],"award-info":[{"award-number":["MOST111-2320-B-038-044"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022600","name":"wan fang hospital","doi-asserted-by":"publisher","award":["111TMU-WFH-14"],"award-info":[{"award-number":["111TMU-WFH-14"]}],"id":[{"id":"10.13039\/501100022600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Therapeutic drug monitoring (TDM) indicators have been suggested to predict overall outcome responses to olanzapine (OLZ) treatments in terms of efficacy and metabolic syndrome. This study aimed to investigate whether paraoxonase-1 (PON-1) activity can be used to predict schizophrenia patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Schizophrenic patients ( N\u2009=\u200950) aged between 20 and 65\u2009years who received OLZ treatment were recruited, and their Positive and Negative Syndrome Scale scores, PON-1 activity, and olanzapine drug levels normalized by dose (OLZ\/D) and its metabolite N-desmethyl-olanzapine (DMO), together with biochemical parameters, were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PON-1 activity and OLZ\/D were significantly correlated in 50 patients (correlation coefficient, r\u2009=\u20090.355; p\u2009=\u20090.0115). There was also a statistically significant correlation between the ratio of PON-1 activity normalized by homocysteine (Hcy) and OLZ\/D (correlation coefficient r\u2009=\u20090.361; p\u2009=\u20090.01) and a significant negative correlation between the ratio of PON-1 activity normalized by Hcy and triglyceride\/high-density lipoprotein (TG\/HDL; correlation coefficient r\u2009=\u2009\u22120.328; p\u2009=\u20090.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PON-1 activity can be used as an alternative tool for monitoring TDM through the measurement of OLZ together with its metabolite, DMO, to identify patients who have higher activity. Those who show an optimal response or who have lower activity might have greater cardiometabolic risk under long-term olanzapine treatment. Longitudinal monitoring is warranted to confirm such observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811241311459","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T07:27:21Z","timestamp":1736234841000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between paraoxonase-1 activity and therapeutic drug monitoring indicators in schizophrenia patients treated with olanzapine: A cross-sectional study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-6248","authenticated-orcid":false,"given":"Tzu-Hua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Chin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nailis","family":"Sylfa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan"},{"name":"Pharmacy Department, Faculty of Health Science, University of Muhammadiyah Malang, Malang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahn-Haur","family":"Liao","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9762-6904","authenticated-orcid":false,"given":"Ahmad","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Psychiatry, Wan Fang Hospital & School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-8193","authenticated-orcid":false,"given":"Mong-Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Psychiatry, Wan Fang Hospital & School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"bibr1-02698811241311459","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10815"},{"key":"bibr2-02698811241311459","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2012.121005"},{"key":"bibr3-02698811241311459","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.047"},{"key":"bibr4-02698811241311459","first-page":"1","volume":"6","author":"Cheraghi 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