{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:21:48Z","timestamp":1785187308937,"version":"3.55.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mellby G\u00e5rd Foundation"},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["FO2022-0001"],"award-info":[{"award-number":["FO2022-0001"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["FO2023-0223"],"award-info":[{"award-number":["FO2023-0223"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004200","name":"Olle Engkvists Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021592","name":"Ekhagastiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Migraine and cluster headache are two primary headache disorders for which conventional treatments are limited. Classic psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin are potentially promising new treatment candidates for these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of the present study was to investigate the possible relationship between the lifetime use of classic psychedelics and frequent bad headaches in a large British cohort sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Using data (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200911,419) collected in 1999\u20132000 as part of the 1958 British National Child Development Study, this cross-sectional study used multiple logistic regression, controlling for a range of potential confounders, to test the hypothesis that lifetime use of classic psychedelics would be associated with lower odds of having frequent bad headaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Lifetime use of classic psychedelics was associated with 25% lower odds of having frequent bad headaches (adjusted odds ratio\u2009=\u20090.75, 95% CI: 0.59\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of the present study add to the literature suggesting classic psychedelics as a possible future prophylactic treatment option for primary headache disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811251324372","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:34:06Z","timestamp":1741768446000},"page":"968-975","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Lifetime classic psychedelic use and headaches: A cross-sectional study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6381-8362","authenticated-orcid":false,"given":"Zusanna","family":"Bjurenfalk","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Centre for Cluster Headache, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alva","family":"Cosmo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Centre for Cluster Headache, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-7566","authenticated-orcid":false,"given":"Otto","family":"Simonsson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0239-9871","authenticated-orcid":false,"given":"Caroline","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Centre for Cluster Headache, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04643-8"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-017-0186-6"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01653-7"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14021"},{"key":"e_1_3_2_6_1","unstructured":"Bynner J Butler N Ferri E et al. (2002) The design and conduct of the 1999-2000 surveys of the national child development study and the 1970 British cohort study Working paper 1. Centre for Longitudinal Studies Institute of Education University of London UK."},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2171"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1984.0404213.x"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01592.x"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540261.2018.1481827"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1780121"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004673"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414547138"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13836"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419845660"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.05.012"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.10.029"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410363490"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01575629"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02091-1"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13203"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1607494.x"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01660-8"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000680"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14656"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414539057"},{"key":"e_1_3_2_29_1","doi-asserted-by":"crossref","unstructured":"Nesbitt AD Goadsby PJ (2012) Cluster headache. BMJ 344: e2407. https:\/\/doi.org\/10.1136\/bmj.e2407","DOI":"10.1136\/bmj.e2407"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.2171"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/J354v20n03_05"},{"key":"e_1_3_2_33_1","article-title":"Medical cannabis, headaches, and migraines: A review of the current literature","volume":"13","author":"Poudel S","year":"2021","unstructured":"Poudel S, Quinonez J, Choudhari J, et al. (2021) Medical cannabis, headaches, and migraines: A review of the current literature. Cureus 13: e17407.","journal-title":"Cureus"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi183"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.842082"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.10.005"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eee244"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.02028.x"},{"key":"e_1_3_2_39_1","unstructured":"R Core Team (2023). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing Vienna Austria. https:\/\/www.R-project.org\/."},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2015.1107664"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122993"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00962-y"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14420"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.11.015"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219761.05466.43"},{"key":"e_1_3_2_46_1","first-page":"19820","article-title":"Unauthorized research on cluster headache","author":"Sewell A","year":"2008","unstructured":"Sewell A (2008) Unauthorized research on cluster headache. Entheogen Rev XVI: 19820.","journal-title":"Entheogen Rev"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae083"},{"key":"e_1_3_2_48_1","volume-title":"NCDS\/BCS70 1999-2000 Follow-ups: Guide to the Combined Dataset, Joint Centre for Longitudinal Research Team","author":"Shepherd P","year":"2001","unstructured":"Shepherd P (2001) NCDS\/BCS70 1999-2000 Follow-ups: Guide to the Combined Dataset, Joint Centre for Longitudinal Research Team. Centre for Longitudinal Studies."},{"key":"e_1_3_2_49_1","first-page":"116","article-title":"Prophylactic treatment of migraine by means of lysergic acid derivatives","volume":"67","author":"Sicuteri F","year":"1963","unstructured":"Sicuteri F (1963) Prophylactic treatment of migraine by means of lysergic acid derivatives. Triangle 67: 116\u2013125.","journal-title":"Triangle"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03034.x"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007787"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12620"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.10.001"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200305000-00005"},{"key":"e_1_3_2_55_1","volume-title":"National Child Development Study: Sweep 6, 1999\u20132000 [Data Collection]. 2nd Release","author":"University of London","year":"2008","unstructured":"University of London (2008) National Child Development Study: Sweep 6, 1999\u20132000 [Data Collection]. 2nd Release. London, UK: UK Data Service. Institute of Education, Centre for Longitudinal Studies."},{"key":"e_1_3_2_56_1","volume-title":"National Child Development Study Ethical Review and Consent","author":"University of London","year":"2014","unstructured":"University of London (2014) National Child Development Study Ethical Review and Consent. Institute of Education, Centre for Longitudinal Studies."},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14663"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2017-0068"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251324372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811251324372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251324372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:12:06Z","timestamp":1777507926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811251324372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/02698811251324372"],"URL":"https:\/\/doi.org\/10.1177\/02698811251324372","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]}}}