{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:59:37Z","timestamp":1782536377150,"version":"3.54.5"},"reference-count":122,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mental disorders, including anxiety and depression, impact nearly 1\u2009billion people worldwide. Recent research has highlighted the potential of certain amphetamine compounds in the therapy of psychiatric disorders, with 3,4-methylenedioxymethamphetamine (MDMA) emerging as a promising candidate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study investigates the effects of MDMA on anxiety and social behaviours using 3-week-old zebrafish. Additionally, the role of oxytocin in regulating these behaviours was examined through the use of an oxytocin receptor agonist (WAY-267,464) and antagonist (L-368,899).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Behavioural effects were assessed using the novel exploration test, light\u2013dark preference test and social preference test. To explore the underlying mechanisms, changes in gene expression in serotonin, oxytocin and vasopressin systems and changes in AKT and EKR1\/2 signalling pathways were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Acute MDMA exposure reduced thigmotactic behaviour and increased the social preference index, indicating anxiolytic and prosocial effects. However, these effects were biphasic \u2013 the lowest tested dose of 0.5\u2009\u03bcM showed anxiogenic and prosocial effects. As the concentration increased, these effects reversed, with a peak at 2.5\u2009\u03bcM. MDMA suppressed the expression of serotonin receptors (\n                      <jats:italic>htr1b<\/jats:italic>\n                      and\n                      <jats:italic>htr2b<\/jats:italic>\n                      ) and transporter (\n                      <jats:italic>scl6a4<\/jats:italic>\n                      ) genes while increasing oxytocin receptors (\n                      <jats:italic>oxtra<\/jats:italic>\n                      and\n                      <jats:italic>oxtrb<\/jats:italic>\n                      ) genes, decreasing vasopressin receptor (\n                      <jats:italic>avpr1aa<\/jats:italic>\n                      ) gene expression, and reducing AKT phosphorylation. The oxytocin receptor agonist mimicked MDMA\u2019s effects, while the antagonist had no significant effect on anxiety or social behaviour.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MDMA demonstrates therapeutic potential for treating anxiety disorders and social impairments. Moreover, 3-week-old zebrafish proved to be a valuable model for neurobehavioural research and high-throughput screening of psychiatric treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811251324596","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:44:58Z","timestamp":1742899498000},"page":"373-393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9866-9612","authenticated-orcid":false,"given":"Monika","family":"Maciag","sequence":"first","affiliation":[{"name":"Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-7890","authenticated-orcid":false,"given":"Olga","family":"Doszyn","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, Warsaw, Poland"},{"name":"Laboratory of Developmental Neurobiology, International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-4225","authenticated-orcid":false,"given":"Artur","family":"Wnorowski","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-8732","authenticated-orcid":false,"given":"Justyna","family":"Zmorzynska","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, Warsaw, Poland"},{"name":"Laboratory of Developmental Neurobiology, International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Budzynska","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119855987"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq5158"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12154"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.5936\/csbj.201401001"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-016-0298-z"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2021.11.001"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.12.007"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.90"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06515.x"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105136"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06184.x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-091718-014723"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_10"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.043877"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn5000056"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10233.1"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00021"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0462"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0593-2"},{"key":"e_1_3_3_21_1","article-title":"A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development","volume":"23","author":"Ciarlo C","year":"2017","unstructured":"Ciarlo C, Kaufman CK, Kinikoglu B, et al (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. ELife 23: e29145.","journal-title":"ELife"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105429"},{"key":"e_1_3_3_23_1","first-page":"759285","article-title":"Zebrafish as a useful tool in the research of natural products with potential anxiolytic effects","volume":"12","author":"Cueto-Escobedo J","year":"2022","unstructured":"Cueto-Escobedo J, German-Ponciano LJ, Guill\u00e9n-Ruiz G, et al (2022) Zebrafish as a useful tool in the research of natural products with potential anxiolytic effects. Front Behav Neurosci 12: 759285.","journal-title":"Front Behav Neurosci"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110769"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1358844"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_3_3_27_1","first-page":"39","article-title":"Development of social behaviour in young zebrafish","volume":"18","author":"Dreosti E","year":"2015","unstructured":"Dreosti E, Lopes G, Kampff AR, et al (2015) Development of social behaviour in young zebrafish. Front Neural Circuits 18: 39.","journal-title":"Front Neural Circuits"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2015.04.003"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470910802649470"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2022.109706"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05990-w"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.101993"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2022_343"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704502"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.08.011"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1978-09.2009"},{"key":"e_1_3_3_37_1","first-page":"319","article-title":"Behavioural effects of developmental exposure to JWH-018 in wild-type and disrupted in schizophrenia 1 (","volume":"11","author":"Garc\u00eda-Gonz\u00e1lez J","year":"2021","unstructured":"Garc\u00eda-Gonz\u00e1lez J, de Quadros B, Havelange W, et al (2021) Behavioural effects of developmental exposure to JWH-018 in wild-type and disrupted in schizophrenia 1 ( disc1) mutant zebrafish. Biomolecules 11: 319.","journal-title":"disc1"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07990-y"},{"key":"e_1_3_3_39_1","article-title":"The zebrafish subcortical social brain as a model for studying social behaviour disorders","volume":"12","author":"Geng Y","year":"2019","unstructured":"Geng Y, Peterson RT (2019) The zebrafish subcortical social brain as a model for studying social behaviour disorders. Dis Models Mechan 12: dmm039446.","journal-title":"Dis Models Mechan"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00061"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67182-4"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.07.017"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107300"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-02093-8"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78744-4"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02311.x"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/cjones"},{"key":"e_1_3_3_48_1","article-title":"\u03b2-Arrestin-dependent ERK signalling reduces anxiety-like and conditioned fear-related behaviours in mice","volume":"14","author":"Jung Ko M","year":"2021","unstructured":"Jung Ko M, Chiang T, Mukadam AA, et al (2021) \u03b2-Arrestin-dependent ERK signalling reduces anxiety-like and conditioned fear-related behaviours in mice. Sci Signal 14: eaba0245.","journal-title":"Sci Signal"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2017"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.12.002"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.016"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910834117"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.04.006"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.12"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1128-0"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.003"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19618-1"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61073-4"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018275108"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0659-17.2017"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00191-9"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.01.003"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.09.024"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114355"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05519"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300185"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.795175"},{"key":"e_1_3_3_69_1","first-page":"145","article-title":"Pharmacotherapy for anxiety disorders: From first-line options to treatment resistance","volume":"19","author":"Melaragno AJ","year":"2021","unstructured":"Melaragno AJ (2021) Pharmacotherapy for anxiety disorders: From first-line options to treatment resistance. Focus (Am Psychiatr Publ) 19: 145\u2013160.","journal-title":"Focus (Am Psychiatr Publ)"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.02.004"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01336-3"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02565-4"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112456611"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13000"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319810111"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12695"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.06.004"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2939-20.2021"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.03.011"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agaa087"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00146"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.08.009"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02225-5"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04879-5"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08503-8"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.10.002"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.125"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1127792"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12834"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56973"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.11.041"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.07.016"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1817"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.03.009"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15348"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.12.016"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2004.10.002"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1143"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.052803"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.025"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328345f758"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41114-y"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470910802045042"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00642"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105704"},{"key":"e_1_3_3_106_1","unstructured":"World Health Organization (2022a) Mental disorders. World Health Organization. (Accessed April 2024). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mental-disorders."},{"key":"e_1_3_3_107_1","unstructured":"World Health Organization (2022b). COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide. World Health Organization. (Accessed April 2024). https:\/\/www.who.int\/news\/item\/02-03-2022-covid-19-pandemic-triggers-25-increase-in-prevalence-of-anxiety-and-depression-worldwide."},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.008"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2178-19.2020"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14524"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1836054.027"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80538-T"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3570-x"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106061514"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75706-1"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56630"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030405"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39434-5"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9705-0_7"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5593-08.2009"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3827-4"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2024.110964"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.05.059"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251324596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811251324596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251324596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:12:06Z","timestamp":1777507926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811251324596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":122,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/02698811251324596"],"URL":"https:\/\/doi.org\/10.1177\/02698811251324596","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]}}}