{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:33:05Z","timestamp":1777858385322,"version":"3.51.4"},"reference-count":79,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000001","name":"national science foundation","doi-asserted-by":"publisher","award":["CHE-1625735"],"award-info":[{"award-number":["CHE-1625735"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS076517"],"award-info":[{"award-number":["NS076517"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA011792"],"award-info":[{"award-number":["DA011792"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA043204"],"award-info":[{"award-number":["DA043204"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA049886"],"award-info":[{"award-number":["DA049886"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA029023"],"award-info":[{"award-number":["AA029023"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA029306"],"award-info":[{"award-number":["AA029306"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["NIAAA"],"award-info":[{"award-number":["NIAAA"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alcohol use disorder patients experience reductions in rapid eye movement (REM) sleep and other sleep problems. Little is known about the pharmacological mechanism(s) involved in this effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      This study compared sleep\u2013wake states and electroencephalography (EEG) spectral power following exposure to ethanol and GABA\n                      <jats:sub>A<\/jats:sub>\n                      receptor (GABA\n                      <jats:sub>A<\/jats:sub>\n                      R) compounds with varying subtype selectivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sprague-Dawley rats received ethanol or subtype-selective GABA\n                      <jats:sub>A<\/jats:sub>\n                      R compounds, followed by EEG\/electromyography (EMG) recordings for 12\u2009h. These recordings were analyzed for sleep\u2013wake state and EEG spectral power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sleep\u2013wake state analysis demonstrated that ethanol, the nonselective compound alprazolam, the \u03b11-selective compound zolpidem, the \u03b12\/3-selective compound KRM-II-81, and the \u03b15-selective compound MP-III-022 produced decreases in REM sleep. By contrast, the \u03b14\/6-selective compound, gaboxadol, only increased time spent in slow-wave sleep (SWS). KRM-II-81 was the only compound to produce increases in time spent awake. The EEG spectral power analysis revealed that all compounds produced a unique signature, but none produced a signature similar to ethanol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Analysis of sleep\u2013wake states after administration of ethanol or GABA\n                      <jats:sub>A<\/jats:sub>\n                      R compounds with varying subtype selectivity suggests that positive modulation of \u03b11, 2, 3, and\/or 5 subunit-containing GABA\n                      <jats:sub>A<\/jats:sub>\n                      Rs is sufficient to suppress REM sleep, and any or all may be involved in ethanol-induced REM sleep suppression. Also, our study suggests that \u03b14\/6 subunit-containing GABA\n                      <jats:sub>A<\/jats:sub>\n                      Rs may be involved in ethanol-induced increases in SWS. The lack of similarity between ethanol and the GABA\n                      <jats:sub>A<\/jats:sub>\n                      R compounds in the pharmaco-EEG analysis suggests that neurotransmitter systems besides the GABAergic system are likely involved in the effects of ethanol on EEG spectral power.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811251344682","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T10:21:37Z","timestamp":1750414897000},"page":"744-755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA\n                    <sub>A<\/sub>\n                    receptor compounds"],"prefix":"10.1177","volume":"39","author":[{"given":"Jaren A","family":"Reeves-Darby","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais F","family":"Berro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather L","family":"Hembree","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P","family":"Shaffery","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-5017","authenticated-orcid":false,"given":"James K","family":"Rowlett","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dishary","family":"Sharmin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prithu","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-9544","authenticated-orcid":false,"given":"Donna M","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA"},{"name":"Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107913"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3789"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108379"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05793-z"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.07.023"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2617-13.2014"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90338-T"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2010.00035.x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38200-X"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108035"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_80"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604304103"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.02.005"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00539.2013"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22350"},{"key":"e_1_3_3_17_1","first-page":"430248","article-title":"A review of the updated pharmacophore for the alpha 5 GABA(A) benzodiazepine receptor model","volume":"2015","author":"Clayton T","year":"2015","unstructured":"Clayton T, Poe MP, Rallapalli S, et al. (2015) A review of the updated pharmacophore for the alpha 5 GABA(A) benzodiazepine receptor model. Int J Med Chem 2015: 430248.","journal-title":"Int J Med Chem"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10763"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.01.017"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04131.x"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2023.1218737"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12006"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244433"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00077-4"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.04.003"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00184.x"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.139"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730406294627"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)24153-2"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2850-20.2021"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2313"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1023"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06680.x"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990341r"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(00)00079-3"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.1109"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2021.04.003"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0446-0"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02651.x"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14325"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246346"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959595"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107923"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23663"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00191-X"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04767"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0866-0"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(78)90272-1"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00008-X"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.045"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2008000900007"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14965"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.11.057"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00442-5"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1189-9"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01332"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-023-06450-3"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173188"},{"key":"e_1_3_3_59_1","first-page":"101","article-title":"Sleep, sleepiness, and alcohol use","volume":"25","author":"Roehrs T","year":"2001","unstructured":"Roehrs T, Roth T (2001) Sleep, sleepiness, and alcohol use. Alcohol Res Health 25: 101\u2013109.","journal-title":"Alcohol Res Health"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3502"},{"key":"e_1_3_3_61_1","unstructured":"SAMHSA Center for Behavioral Health Statistics and Quality (2021) 2021 National Survey on Drug Use and Health. Table 5.6B\u2014Ethanol use disorder in past year: among people aged 12 or older; by age group and demographic characteristics percentages. Available at: https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt39441\/NSDUHDetailedTabs2021\/NSDUHDetailedTabs2021\/NSDUHDetTabsSect5pe2021.htm#tab5.6b (accessed 11 January 2023)."},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811241286760"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13483"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24910"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.09.016"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01236-w"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1994.tb03868.x"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020202806759"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.30"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.05.078"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119230"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.10.004"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21573"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991220)415:3<313::AID-CNE2>3.0.CO;2-7"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2017.04.006"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1993.31"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14979"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02765-w"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03467-4"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0288-9"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251344682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811251344682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251344682","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811251344682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:12:15Z","timestamp":1777507935000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811251344682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":79,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/02698811251344682"],"URL":"https:\/\/doi.org\/10.1177\/02698811251344682","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]}}}