{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:24:01Z","timestamp":1787185441550,"version":"build-2736575974"},"reference-count":74,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH NIDA","award":["DA02812"],"award-info":[{"award-number":["DA02812"]}]},{"name":"National Institutes of Health\u2019s National Center for Advancing Translational Sciences","award":["TL1TR001423"],"award-info":[{"award-number":["TL1TR001423"]}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["T32 NS047987, T32 GM07019"],"award-info":[{"award-number":["T32 NS047987, T32 GM07019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lysergic acid diethylamide (LSD) has been considered as a potential treatment for depression for over 75\u2009years, but its therapeutic potential has only recently been considered in mainstream psychiatry. Repeated ingestion of low doses of LSD (\u201cmicrodoses\u201d) is thought to reduce depression, but the neurobiology underlying this effect is unknown. We previously reported that low doses of LSD increased event-related potentials (ERPs) during receipt of monetary rewards in healthy adults. LSD also produced more positive subjective effects in participants with mild-to-moderate baseline symptoms of depressed mood, compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In this report, we examined the effects of LSD on reward ERPs in participants with mild-to-moderate depressed mood and in non-depressed controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participants with subclinical mild-to-moderate depression (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200920) or controls with minimal symptoms (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200919) received LSD (26\u2009\u03bcg tartrate) or placebo on two sessions. Primary measures were ERPs during a reward task, and secondary measures included self-reported mood during and 48\u2009hours after the sessions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>LSD (vs placebo) increased late positive potential (LPP) amplitude to loss (vs win) reward feedback only in participants with higher baseline depressed mood, suggesting enhanced affective processing given the role of LPP in emotional valuation of reward. This effect of LSD on LPP was associated with its acute positive mood effects, and with lower depressed mood 48-hour after the LSD (vs placebo) session. In the full sample, LSD (vs placebo) decreased feedback-P3 and LPP amplitude to reward (vs neutral) feedback.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although findings must be interpreted with caution, results support the idea that low doses of LSD have potential anti-depressant effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811251405686","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:16:01Z","timestamp":1768349761000},"page":"1368-1380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reward-related neural activity after low doses of LSD in participants with depressed mood"],"prefix":"10.1177","volume":"40","author":[{"given":"James","family":"Glazer","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Northwestern University, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-4512","authenticated-orcid":false,"given":"Hanna","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royce","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Nusslock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Northwestern University, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-8994","authenticated-orcid":false,"given":"Harriet","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102492"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00199"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.04.007"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125314527985"},{"key":"e_1_3_3_7_1","volume-title":"Beck Depression Inventory\u2013II (BDI-II)","author":"Beck AT","year":"1996","unstructured":"Beck AT, Steer RA, Brown G (1996) Beck Depression Inventory\u2013II (BDI-II). 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