{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:13:08Z","timestamp":1790100788612,"version":"4.0.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Serotonergic psychedelics are being investigated in the treatment of various disorders and in the improvement of well-being. Evidence suggests that their subjective effects may play a role in long-term behavioral outcomes. The subjective effects are mediated by 5-HT\n                      <jats:sub>2A<\/jats:sub>\n                      receptor agonism, but the 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor may also play a role in the subjective effects. This study elucidates the effects of 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor blockade using pindolol pre-treatment on the subjective effects induced by\n                      <jats:italic toggle=\"yes\">N,N<\/jats:italic>\n                      -dimethyltryptamine (DMT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a double-blind, randomized, placebo-controlled within-subjects design, 12 (10 males, 2 females) experienced hallucinogen-using participants received a sub-hallucinogenic dose of intravenous DMT fumarate, 0.1\u2009mg\/kg, after pre-treatment with 30\u2009mg oral racemic pindolol. Subjective effects were measured using the Hallucinogen Rating Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Pindolol pre-treatment increased DMT-induced subjective effects with a moderate effect size (\n                      <jats:italic toggle=\"yes\">M<\/jats:italic>\n                      \u2009=\u20090.514). Blood pressure and mean arterial pressure also increased with pindolol pre-treatment at 2\u2009minutes following DMT administration, but heart rate was not affected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor blockade results in a global intensification of DMT-induced subjective effects, suggesting a functional role of 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor action in the mechanism of psychedelic-induced subjective effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811261443696","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:14:21Z","timestamp":1777713261000},"page":"1261-1269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["5-HT\n                    <sub>1A<\/sub>\n                    receptor blockade potentiates the subjective effects of DMT"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-3409","authenticated-orcid":false,"given":"Zarmeen","family":"Zahid","sequence":"first","affiliation":[{"name":"Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick J.","family":"Strassman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, University of New Mexico, Albuquerque, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Qualls","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, University of New Mexico, Albuquerque, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-0639","authenticated-orcid":false,"given":"Sandeep M.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.01.015"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14138.x"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116040"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1333"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892905774597191"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118769063"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811211050543"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00578.x"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00513"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.01.108"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110388326"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw075"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.12.009"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.005"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245219"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050740"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_478"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01159-1"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0324-9"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)39169-X"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1455902"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1112-x"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.01.005"},{"key":"e_1_3_2_26_1","unstructured":"R Core Team (2025) R: A language and environment for statistical computing. 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