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Increase in the frequency and severity of panic attacks was the most frequent finding (14 patients), followed by psycho- stimulant (jitteriness; n=9), depressive (n=8) and tonic anxiety symptoms (n=7). This pattern of initial worsening is different from the 'jitteriness syndrome' described for other antidepressants. Its implications for the understanding of the pathophysiology of panic disorder are discussed.<\/jats:p>","DOI":"10.1177\/026988119300700305","type":"journal-article","created":{"date-parts":[[2007,3,17]],"date-time":"2007-03-17T23:45:17Z","timestamp":1174175117000},"page":"265-269","source":"Crossref","is-referenced-by-count":31,"title":["Clomipramine and initial worsening in panic disorder: beyond the 'jitteriness syndrome'"],"prefix":"10.1177","volume":"7","author":[{"given":"Renato T.","family":"Ramos","sequence":"first","affiliation":[{"name":"Instituto de Psiquiatria, Hospital das Clinicas, FMUSP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentim","family":"Gentil","sequence":"additional","affiliation":[{"name":"LIM-23, Departamento de Psiquiatria, FMUSP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice","family":"Gorenstein","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.8.1014"},{"key":"atypb2","first-page":"479","volume":"52","author":"Brewerton T.D.","year":"1991","journal-title":"J Clin Psychiatr"},{"key":"atypb3","first-page":"123","volume":"34","author":"Caetano D.","year":"1985","journal-title":"J Bras Psiq"},{"key":"atypb4","unstructured":"Cazzullo C.L. 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