{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:32:31Z","timestamp":1777858351192,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>\n                    The 5-HT\n                    <jats:sub>1<\/jats:sub>\n                    receptor agonist GR46611 (3-30 mg\/kg s.c.) caused a dose-related decrease in rectal temperature in the adult guinea-pig. A lower dose (20 \u03bcg) administered directly into the lateral cerebral ventricle also caused a hypothermic response, suggesting that this effect is centrally mediated. GR46611-induced (10 mg\/kg s.c.) hypothermia was not attenuated by WAY100135 (3-10 mg\/kg s.c.), ritanserin (0.3-1 mg\/kg s.c.), spiperone (0.1-0.3 mg\/kg s.c.) and ondansetron (0.1-1 mg\/kg s.c.), suggesting that 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    , 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    , 5-HT\n                    <jats:sub>2C<\/jats:sub>\n                    and 5-HT\n                    <jats:sub>3<\/jats:sub>\n                    receptors are unlikely to be involved in this response. In contrast, the poorly selective 5-HT receptor antagonist, metergoline (1-10 mg\/kg s.c.), and the potent 5-HT\n                    <jats:sub>1D<\/jats:sub>\n                    receptor antagonist, GR127935 (0.1-1 mg\/kg p.o.), antagonized the effects of GR46611. The present data suggest that antagonism of GR46611-induced hypothermia may be useful for assessing the potency and duration of action of centrally-acting 5-HT\n                    <jats:sub>1D<\/jats:sub>\n                    receptor antagonists in the guinea-pig.\n                  <\/jats:p>","DOI":"10.1177\/026988119400800103","type":"journal-article","created":{"date-parts":[[2007,3,17]],"date-time":"2007-03-17T23:45:17Z","timestamp":1174175117000},"page":"14-21","source":"Crossref","is-referenced-by-count":49,"title":["Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig"],"prefix":"10.1177","volume":"8","author":[{"given":"M.","family":"Skingle","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, Glaxo Group Research, Ware, Hertfordsire SG12 ODP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Glaxo Unit of Behavioural Psychopharmacology, Department of Biosciences, University of Hertfordshire, College Lane, Hatfield, Hertfordshire AL10 9AB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Feniuk","sequence":"additional","affiliation":[{"name":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12342.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90588-4"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1986.tb10832.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199006001-00005"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(81)90101-7"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014634"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90280-U"},{"key":"atypb8","volume-title":"Statistical methods in bioassay","author":"Finney D.J.","year":"1964","edition":"2"},{"key":"atypb9","unstructured":"Green A.R., Goodwin G.M. 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