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Significant differences between the groups in terms of total positive or total negative symptoms were not demonstrated, but the pattern of change between the treatment groups differed, so that benefit in positive symptomatology was seen in both intensive treatment groups and in negative symptomatology in the intensive treatment\/risperidone group and the standard group. Changes in general psychopathology were most marked in the risperidone group and were compatible with a relatively non-sedative profile. Using the Disability Assessment Schedule, substantial significant advantages for the intensive treatment groups were found. <\/jats:p>","DOI":"10.1177\/026988119701100411","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T21:43:24Z","timestamp":1212443004000},"page":"349-356","source":"Crossref","is-referenced-by-count":5,"title":["A study of enhanced management in patients with treatment-resistant schizophrenia"],"prefix":"10.1177","volume":"11","author":[{"given":"Gavin","family":"Mercer","sequence":"first","affiliation":[{"name":"University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Finlayson","sequence":"additional","affiliation":[{"name":"University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve C.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Murray","sequence":"additional","affiliation":[{"name":"University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G. 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