{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:37:50Z","timestamp":1762954670425,"version":"3.38.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p> The hypothesis that N-methyl-D-aspartate (NMDA) receptors mediate initiation of lasting behavioral changes induced by the anxiogenic \u03b2-carboline, FG-7142, was supported in this study. Behavioral changes normally induced by FG-7142 were blocked when the competitive NMDA receptor blocker, 7-amino-phophono-heptanoic acid, was given prior to administration of FG-7142. When cats were subsequently given FG-7142 alone, the drug produced lasting behavioral changes like those reported previously. Flumazenil, a benzodiazepine receptor antagonist, reversed an increase in defensiveness produced by FG-7142 alone, replicating previous findings. The data are consistent with the hypothesis that NMDA-dependent long-term potentiation in limbic pathways subserving defensive response to threat mediates lasting increases in defensiveness produced by FG-7142. <\/jats:p>","DOI":"10.1177\/026988119801200203","type":"journal-article","created":{"date-parts":[[2007,3,18]],"date-time":"2007-03-18T03:45:17Z","timestamp":1174189517000},"page":"129-136","source":"Crossref","is-referenced-by-count":19,"title":["Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior"],"prefix":"10.1177","volume":"12","author":[{"given":"Robert E.","family":"Adamec","sequence":"first","affiliation":[{"name":"Department of Psychology, Memorial University, St. John's, Newfoundland A1B 3X9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90264-O"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/026988119100500107"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90247-D"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/026988119300700302"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/026988119801200202"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/026988119801200204","volume":"12","author":"Adamec RE","year":"1998","journal-title":"J Psychopharmac"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(80)91256-X"},{"key":"atypb8","unstructured":"Andrew R.J. (1972) The information potentially available in mammal displays. In Hinde RA (ed.), Non-verbal communication. London: Cambridge University Press, pp. 204-206"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1163\/156853963X00185"},{"key":"atypb10","first-page":"1","volume":"2","author":"Leyhausen P.","year":"1956","journal-title":"Z Tierpsychol"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91438-9"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988119801200203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988119801200203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:33:48Z","timestamp":1740875628000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026988119801200203"}},"subtitle":["Study 2 - The effects on behavior of block of NMDA receptors prior to injection of FG-7142"],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1177\/026988119801200203"],"URL":"https:\/\/doi.org\/10.1177\/026988119801200203","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"type":"print","value":"0269-8811"},{"type":"electronic","value":"1461-7285"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}