{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:54:13Z","timestamp":1759694053804,"version":"3.38.0"},"reference-count":73,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p> Microinjection of a serotonergic 5-HT<jats:sub>1B<\/jats:sub> agonist (S-CM-GTNH<jats:sub>2<\/jats:sub>, 3\u03bcg\/l) into the dorsal subiculum (DS) induced long-lasting increases in dopamine (DA; +58%), dihydroxyphenylacetic acid (DOPAC; +15%) and homovanillic acid (HVA; +31%), without changing extracellular levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), measured by microdialysis in freely moving rats in the shell area of the nucleus accumbens (n. acc). Perfusion of a glutamate-N-methyl-D-aspartate (NMDA) receptor antagonist (MK 801, dizocilpine, 10\u03bcM) through the dialysis probe in the n. acc induced similar long-lasting increases in DA and DOPAC, whereas the glutamate-quisqualate\/kainate receptor antagonist (CNQX, 50 \u03bcM) had no effect. In the presence of dizocilpine in the n. acc, microinjection of S-CM-GTNH<jats:sub>2<\/jats:sub> into the DS could still increase DOPAC and HVA, but DA levels were not further changed, whereas in the presence of CNQX, microinjection of S-CM-GTNH<jats:sub>2<\/jats:sub> into the DS still increased not only DOPAC and HVA, but also DA levels in a way similar to that in the absence of glutamate antagonist. Therefore, activation of 5-HT<jats:sub>1B<\/jats:sub> receptors located in the DS increases the release of DA in the n. acc, presumably via the glutamatergic projection to this structure and acting through NMDA receptors in it. This implies either the suppression of a tonic indirect inhibitory influence and\/or stimulation of a phasic excitatory effect of glutamate. <\/jats:p><jats:p> Disruption of latent inhibition (LI) has been suggested as a model for a cognitive deficit in schizophrenia (hyperattention to irrelevant stimuli) and is usually associated with an increase in DA release in the n. acc. However, s.c. injection of RU 24 969 (0.5 mg\/kg), a mixed 5-HT<jats:sub>1A<\/jats:sub>-5-HT<jats:sub>1B<\/jats:sub> agonist, which was previously shown to increase DA release in the n. acc, left LI unchanged. Moreover, bilateral microinjections of S-CM-GTNH<jats:sub>2<\/jats:sub> into the rat DS tended to potentiate LI, in spite of the increase in DA in n. acc demonstrated here. It is concluded that not all increases in DA release in the n. acc are functionally equivalent. Sensitization of receptors or impulse- dependent increase in DA release might be necessary to disrupt LI. The possible role of altered serotonergic transmission, through h5-HT<jats:sub>1B<\/jats:sub> receptors (human homologue of the rat 5-HT<jats:sub> 1B<\/jats:sub> receptors) located in the DS, in acute schizophrenia needs to be further investigated. <\/jats:p>","DOI":"10.1177\/026988119801200305","type":"journal-article","created":{"date-parts":[[2007,3,18]],"date-time":"2007-03-18T03:45:17Z","timestamp":1174189517000},"page":"258-267","source":"Crossref","is-referenced-by-count":18,"title":["Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5 -HT1B agonist into the dorsal subiculum: implications for schizophrenia"],"prefix":"10.1177","volume":"12","author":[{"given":"P.","family":"Boulenguez","sequence":"first","affiliation":[{"name":"present address: INSERM U297, Lab. de Neuroendocrinologie Experimentale, UER de medicine Nord, Boulevard Pierre Drammard, 13916 Marseille Cedex 20, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.N.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"present address: Lilly Research Centre Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PHand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chauveau","sequence":"additional","affiliation":[{"name":"Immunotech S.A.,130 avenue J. 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