{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T14:28:10Z","timestamp":1749047290270,"version":"3.38.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p> This case report documents the response of a young, first-episode, neuroleptic naive male with severe catatonic schizophrenia to the novel antipsychotic, risperidone. Initial assessments included the Positive and Negative Syndrome Scales, Global Assessment of Function and the Extrapyramidal Symptom Rating Scale. These were repeated at discharge from hospital and during a 3.5 year outpatient follow-up. Neuroimaging (computed tomography, magnetic resonance imaging and single photon emission tomography) along with electro encephalogram and laboratory examinations were completed. Response to risperidone was prompt, dramatic and sustained over the follow-up period. Possible neurochemical brain mechanisms resulting in catatonia and the role of serotonin\/dopamine antagonists such as risperidone are discussed. No other literature on the effect of risperidone in the treatment of severe catatonic schizophrenia in a first-episode patient has been reported. <\/jats:p>","DOI":"10.1177\/026988119801200312","type":"journal-article","created":{"date-parts":[[2007,3,18]],"date-time":"2007-03-18T03:45:17Z","timestamp":1174189517000},"page":"314-317","source":"Crossref","is-referenced-by-count":20,"title":["Acute and longer-term effects of risperidone in a case of first-episode catatonic schizophrenia"],"prefix":"10.1177","volume":"12","author":[{"given":"Lili C.","family":"Kopala","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"atypb1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4"},{"volume-title":"Dementia praecox","year":"1950","author":"Bleuler E.","key":"atypb2"},{"doi-asserted-by":"publisher","key":"atypb3","DOI":"10.1111\/j.1600-0447.1996.tb09815.x"},{"doi-asserted-by":"publisher","key":"atypb4","DOI":"10.1176\/ajp.152.12.1724"},{"key":"atypb5","first-page":"233","volume":"7","author":"Chouinard G.","year":"1980","journal-title":"Can J Neurol Sci"},{"doi-asserted-by":"publisher","key":"atypb6","DOI":"10.1097\/00004714-199302000-00004"},{"doi-asserted-by":"publisher","key":"atypb7","DOI":"10.1001\/archpsyc.1996.01830010084011"},{"doi-asserted-by":"publisher","key":"atypb8","DOI":"10.1177\/026988119701100206"},{"doi-asserted-by":"publisher","key":"atypb9","DOI":"10.1016\/0925-4927(92)90019-Z"},{"key":"atypb10","first-page":"2","volume":"7","author":"Fink M.","year":"1991","journal-title":"Integ Psychiat"},{"doi-asserted-by":"crossref","unstructured":"Guy W. ( 1976) ECDEU assessment manual for psychopharmacology (revised) . US Department of Health, Education, and Welfare publication ADM 76-388, Rockville, MD","key":"atypb11","DOI":"10.1037\/e591322011-001"},{"doi-asserted-by":"publisher","key":"atypb12","DOI":"10.2190\/X0FF-VU7G-QQP7-L5V7"},{"doi-asserted-by":"publisher","key":"atypb13","DOI":"10.1001\/archpsyc.1995.03950210050010"},{"doi-asserted-by":"publisher","key":"atypb14","DOI":"10.1192\/bjp.162.6.733"},{"volume-title":"Die Katatonie, oder das Spannungs Irresein","year":"1874","author":"Kahlbaum K.L.","key":"atypb15"},{"doi-asserted-by":"publisher","key":"atypb16","DOI":"10.1016\/0024-3205(95)02037-J"},{"doi-asserted-by":"publisher","key":"atypb17","DOI":"10.1093\/schbul\/13.2.261"},{"doi-asserted-by":"publisher","key":"atypb18","DOI":"10.1016\/0006-3223(95)00500-5"},{"doi-asserted-by":"publisher","key":"atypb19","DOI":"10.1097\/00004714-199708000-00011"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.3109\/13651509809115109","volume":"2","author":"Kopala L.","year":"1998","journal-title":"Int J Psychiat Clin Pract"},{"unstructured":"Leysen J.E., Gommeren W., Schotte A. (1996) Serotonin receptor subtypes: possible roles and implications in antipsychotic drug action. In Kane J M, Moller H J, Awouters F (eds), Serotoninin antipsychotic treatment: mechanisms and clinical practice. Marcel Dekker , New York, pp. 51-75","key":"atypb21"},{"unstructured":"London ED, Steven JG, Morgan MJ, Stephen RZ (1996) Neurobiology of drug abuse. In Fogel B S, Schiffer R B, Rao S M (eds), Neuropsychiatry. Williams & Wilkins, Baltimore, MD, pp. 653-657","key":"atypb22"},{"doi-asserted-by":"publisher","key":"atypb23","DOI":"10.1176\/ajp.151.6.825"},{"doi-asserted-by":"publisher","key":"atypb24","DOI":"10.1136\/jnnp.62.4.404"},{"doi-asserted-by":"publisher","key":"atypb25","DOI":"10.1192\/bjp.165.4.548"},{"doi-asserted-by":"publisher","key":"atypb26","DOI":"10.1176\/jnp.6.1.1"},{"key":"atypb27","first-page":"187","volume":"52","author":"Rosebush P.I.","year":"1991","journal-title":"J Clin Psychiat"},{"key":"atypb28","first-page":"357","volume":"51","author":"Rosebush P.I.","year":"1990","journal-title":"J Clin Psychiat"},{"doi-asserted-by":"publisher","key":"atypb29","DOI":"10.1176\/ajp.149.9.1279"},{"unstructured":"Sackeim H.A., Stern Y. (1997) Neuropsychiatric aspects of memory and amnesia . In Yudofsky S C and Hales R E (eds), Textbook of neuropsychiatry , 3rd edn. American Psychiatric Press, Washington DC, pp. 501-518","key":"atypb30"},{"doi-asserted-by":"publisher","key":"atypb31","DOI":"10.1016\/0925-4927(93)90001-X"},{"key":"atypb32","first-page":"48","volume":"3","author":"Taylor M.A.","year":"1990","journal-title":"Neuropsychiat Neuropsychol Behav Neurol"},{"doi-asserted-by":"publisher","key":"atypb33","DOI":"10.1001\/archpsyc.1995.03950220039008"},{"doi-asserted-by":"publisher","key":"atypb34","DOI":"10.1111\/j.1600-0447.1994.tb01515.x"},{"doi-asserted-by":"publisher","key":"atypb35","DOI":"10.1016\/0006-3223(91)90152-C"},{"doi-asserted-by":"publisher","key":"atypb36","DOI":"10.1097\/00004714-199002000-00024"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988119801200312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988119801200312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T14:41:01Z","timestamp":1740926461000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026988119801200312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1177\/026988119801200312"],"URL":"https:\/\/doi.org\/10.1177\/026988119801200312","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"type":"print","value":"0269-8811"},{"type":"electronic","value":"1461-7285"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}