{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:30:06Z","timestamp":1759530606412,"version":"3.38.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p> Several placebo-controlled trials have shown the effcacy of clomipramine (CMI) in panic disorder. However, none has investigated the relationship between CMI, and desmethylclomipramine (DCMI) plasma levels, and outcome. In this trial, 41 patients meeting the DSM-III-R criteria for panic disorder with\/without agoraphobia received 50-200 mg of CMI daily in a single-blind, flexible dose regimen for 14 weeks. At the end of treatment, 97% of the patients were free of panic attacks. Patients were classified into two groups of improvement according to the panic symptom items of the `Patient-Rated Anxiety Scale'. A repeated-measures analysis of variance suggested a significant association between outcome and serum DCMI level\/daily dose ratio as well as total serum level\/daily dose. Patients with intense improvement showed DCMI and total serum levels lower than those with moderate improvement. The results indicate the importance of monitoring clomipramine and desmethylclomipramine serum levels in this disorder. <\/jats:p>","DOI":"10.1177\/026988119901300105","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T23:04:54Z","timestamp":1238627094000},"page":"40-44","source":"Crossref","is-referenced-by-count":11,"title":["Serum levels of clomipramine and desmethylclomipramine and clinical                 improvement in panic disorder"],"prefix":"10.1177","volume":"13","author":[{"given":"T.","family":"Marcourakis","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias                         Biom\u00e9dicas; Centro de Investiga\u00e7\u00f5es em                         Neurologia, Hospital das Cl\u00ednicas\/FMUSP (LIM-15),"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gorenstein","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias                         Biom\u00e9dicas; Instituto de Psiquiatria, Hospital das                         Cl\u00ednicas\/FMUSP (LIM-23)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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