{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:07:14Z","timestamp":1790460434382,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T00:00:00Z","timestamp":1443744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    We have recently reported cannabinoid-induced rapid changes in the structure of individual neurons. In order to investigate the presence of similar effects at the regional level, measures of brain tissue biomechanics are required. However, cannabinoids are known to alter cerebral blood flow (CBF), putatively resulting in presently unexplored changes in cerebral tissue biomechanics. Here we used magnetic resonance elastography (MRE) and flow-sensitive alternating inversion recovery (FAIR) imaging to measure in\u00a0vivo alterations of mechanical properties and CBF, respectively, in the rat hippocampus, a brain region with a high density of type-1 cannabinoid receptors (CB\n                    <jats:sub>1<\/jats:sub>\n                    R). Systemic injection of the cannabinoid agonist CP55,940 (0.7\u2009mg\/kg) induced a significant stiffness decrease of 10.5\u2009\u00b1\u20091.2% at 15 minutes. FAIR imaging indicated a comparable decrease (11.3\u2009\u00b1\u20091.9%) in CBF. Both effects were specific to CB\n                    <jats:sub>1<\/jats:sub>\n                    R activation, as shown by pretreatment with the CB\n                    <jats:sub>1<\/jats:sub>\n                    R-specific antagonist AM251. Strikingly, similar rapid parallel changes of brain elasticity and CBF were also observed after systemic treatment with the hypotensive drug nicardipine. Our results reveal important drug-induced parallel changes in CBF and brain mechanical characteristics, and show that blood flow-dependent tissue softening has to be considered as an important putative confounding factor when cerebral viscoelastic changes are investigated.\n                  <\/jats:p>","DOI":"10.1177\/0271678x15606923","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:41:00Z","timestamp":1449236460000},"page":"954-964","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cannabinoid receptor activation in the juvenile rat brain results in rapid biomechanical alterations: Neurovascular mechanism as a putative confounding factor"],"prefix":"10.1177","volume":"36","author":[{"given":"Simon","family":"Chatelin","sequence":"first","affiliation":[{"name":"Laboratory of Imaging Biomarkers, UMR1149 INSERM-University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Humbert-Claude","sequence":"additional","affiliation":[{"name":"Brain Plasticity Unit, CNRS UMR8249, ESPCI-ParisTech, PSL Research University, Paris, France"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Garteiser","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, UMR1149 INSERM-University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ricobaraza","sequence":"additional","affiliation":[{"name":"Brain Plasticity Unit, CNRS UMR8249, ESPCI-ParisTech, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Vilgrain","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, UMR1149 INSERM-University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Department of Radiology, Assistance-Publique H\u00f4pitaux de Paris, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard E","family":"Van Beers","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, UMR1149 INSERM-University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Department of Radiology, Assistance-Publique H\u00f4pitaux de Paris, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Sinkus","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, UMR1149 INSERM-University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Lenkei","sequence":"additional","affiliation":[{"name":"Brain Plasticity Unit, CNRS UMR8249, ESPCI-ParisTech, PSL Research University, Paris, France"},{"name":"These authors contributed equally to this 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