{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:45:59Z","timestamp":1790689559169,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia\/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. Our aim was to assess whether RIPostC is protective following cerebral hypoxia-ischemia in a piglet model of neonatal encephalopathy (NE) using magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry. After hypoxia-ischemia (HI), 16 Large White female newborn piglets were randomized to: (i) no intervention ( n\u2009=\u20098); (ii) RIPostC \u2013 with four, 10-min cycles of bilateral lower limb ischemia\/reperfusion immediately after HI ( n\u2009=\u20098). RIPostC reduced the hypoxic-ischemic-induced increase in white matter proton MRS lactate\/N acetyl aspartate ( p\u2009=\u20090.005) and increased whole brain phosphorus-31 MRS ATP ( p\u2009=\u20090.039) over the 48\u2009h after HI. Cell death was reduced with RIPostC in the periventricular white matter ( p\u2009=\u20090.03), internal capsule ( p\u2009=\u20090.002) and corpus callosum ( p\u2009=\u20090.021); there was reduced microglial activation in corpus callosum ( p\u2009=\u20090.001) and more surviving oligodendrocytes in corpus callosum ( p\u2009=\u20090.029) and periventricular white matter ( p\u2009=\u20090.001). Changes in gene expression were detected in the white matter at 48\u2009h, including K\n                    <jats:sub>ATP<\/jats:sub>\n                    channel and endothelin A receptor. Immediate RIPostC is a potentially safe and promising brain protective therapy for babies with NE with protection in white but not grey matter.\n                  <\/jats:p>","DOI":"10.1177\/0271678x15608862","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:42:56Z","timestamp":1449236576000},"page":"1396-1411","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter"],"prefix":"10.1177","volume":"36","author":[{"given":"Mojgan","family":"Ezzati","sequence":"first","affiliation":[{"name":"Institute for Women\u2019s Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bainbridge","sequence":"additional","affiliation":[{"name":"Physics and Bioengineering, University College 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