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We showed that progesterone (8\u2009mg\/kg at 1\u2009h post-middle cerebral occlusion) restored the mitochondrial reduced glutathione pool and the nicotinamide adenine dinucleotide-linked respiration in both sexes. Progesterone also reversed the decrease of the flavin adenine dinucleotide-linked respiration, which was only observed in females. Our findings point to a sex difference in stroke effects on the brain respiratory chain and suggest that the actions of progesterone on mitochondrial function may participate in its neuroprotective properties.<\/jats:p>","DOI":"10.1177\/0271678x15610338","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:45:38Z","timestamp":1449236738000},"page":"562-568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Progesterone reduces brain mitochondrial dysfunction after transient focal ischemia in male and female mice"],"prefix":"10.1177","volume":"36","author":[{"given":"Pauline","family":"Gaignard","sequence":"first","affiliation":[{"name":"U1195 Inserm and University Paris-Sud, Le Kremlin-Bic\u00eatre, France"},{"name":"Biochemistry Laboratory, Bic\u00eatre Hospital, Assistance-Publique H\u00f4pitaux de Paris, University Paris-Sud, Le Kremlin-Bic\u00eatre Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Fr\u00e9chou","sequence":"additional","affiliation":[{"name":"U1195 Inserm and University Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schumacher","sequence":"additional","affiliation":[{"name":"U1195 Inserm and University Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Th\u00e9rond","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Bic\u00eatre Hospital, Assistance-Publique H\u00f4pitaux de Paris, University Paris-Sud, Le Kremlin-Bic\u00eatre Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mattern","sequence":"additional","affiliation":[{"name":"M et P Pharma AG, Emmetten, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhamid","family":"Slama","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Bic\u00eatre Hospital, Assistance-Publique H\u00f4pitaux de Paris, University Paris-Sud, Le Kremlin-Bic\u00eatre Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Guennoun","sequence":"additional","affiliation":[{"name":"U1195 Inserm and University Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"bibr1-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1177\/1073858409333069"},{"key":"bibr2-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.09.003"},{"key":"bibr3-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1227"},{"key":"bibr4-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.09.014"},{"key":"bibr5-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600059"},{"key":"bibr6-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1913"},{"key":"bibr7-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.002"},{"key":"bibr8-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.05.033"},{"key":"bibr9-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.62"},{"key":"bibr10-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00836.x"},{"key":"bibr11-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.01.025"},{"key":"bibr12-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn184"},{"key":"bibr13-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.6.0008"},{"key":"bibr14-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014731"},{"key":"bibr15-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.015"},{"key":"bibr16-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1021\/bi901627u"},{"key":"bibr17-0271678X15610338","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr132"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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