{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:39:44Z","timestamp":1790411984582,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    Alcoholism is associated with widespread brain structural abnormalities affecting mainly the frontocerebellar and the Papez\u2019s circuits. Brain glucose metabolism has received limited attention, and few studies used regions of interest approach and showed reduced global brain metabolism predominantly in the frontal and parietal lobes. Even though these studies have examined the relationship between grey matter shrinkage and hypometabolism, none has performed a direct voxel-by-voxel comparison between the degrees of structural and metabolic abnormalities. Seventeen alcoholic patients and 16 control subjects underwent both structural magnetic resonance imaging and\n                    <jats:sup>18<\/jats:sup>\n                    F-2-fluoro-deoxy-glucose-positron emission tomography examinations. Structural abnormalities and hypometabolism were examined in alcoholic patients compared with control subjects using two-sample t-tests. Then, these two patterns of brain damage were directly compared with a paired t-test. Compared to controls, alcoholic patients had grey matter shrinkage and hypometabolism in the fronto-cerebellar circuit and several nodes of Papez\u2019s circuit. The direct comparison revealed greater shrinkage than hypometabolism in the cerebellum, cingulate cortex, thalamus and hippocampus and parahippocampal gyrus. Conversely, hypometabolism was more severe than shrinkage in the dorsolateral, premotor and parietal cortices. The distinct profiles of abnormalities found within the Papez\u2019s circuit, the fronto-cerebellar circuit and the parietal gyrus in chronic alcoholism suggest the involvement of different pathological mechanisms.\n                  <\/jats:p>","DOI":"10.1177\/0271678x15611136","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:45:16Z","timestamp":1449236716000},"page":"1625-1640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism"],"prefix":"10.1177","volume":"36","author":[{"given":"Ludivine","family":"Ritz","sequence":"first","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Segobin","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Lannuzel","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Boudehent","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"},{"name":"Centre Hospitalier Universitaire, Service D\u2019Addictologie, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vabret","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"},{"name":"Centre Hospitalier Universitaire, Service D\u2019Addictologie, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Eustache","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Beaunieux","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L","family":"Pitel","sequence":"additional","affiliation":[{"name":"INSERM, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Caen, France"},{"name":"Ecole Pratique des Hautes Etudes, Caen, France"},{"name":"Centre Hospitalier Universitaire, Caen, 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