{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:14:29Z","timestamp":1789409669190,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    We recently showed that Alzheimer's disease patients have lower plasma concentrations of the phosphatidylcholines (PC16:0\/20:5; PC16:0\/22:6; and PC18:0\/22:6) relative to healthy controls. We now extend these findings by examining associations between plasma concentrations of these PCs with cognition and brain function (measured by regional resting state cerebral blood flow; rCBF) in non-demented older individuals. Within the Baltimore Longitudinal Study of Aging neuroimaging substudy, participants underwent cognitive assessments and brain\n                    <jats:sup>15<\/jats:sup>\n                    O-water positron emission tomography. Plasma phosphatidylcholines concentrations (PC16:0\/20:5, PC16:0\/22:6, and PC18:0\/22:6), cognition (California Verbal Learning Test (CVLT), Trail Making Test A&amp;B, the Mini-Mental State Examination, Benton Visual Retention, Card Rotation, and Fluencies\u2014Category and Letter), and rCBF were assessed. Lower plasma phosphatidylcholine concentrations were associated with lower baseline memory performance (CVLT long delay recall task\u2014PC16:0\/20:5:\n                    <jats:sub>\u22122.17<\/jats:sub>\n                    \u20131.39\n                    <jats:sub>\u22120.60<\/jats:sub>\n                    p\u2009=\u20090.001 (\u03b2 with 95% confidence interval subscripts)) and lower rCBF in several brain regions including those associated with memory performance and higher order cognitive processes. Our findings suggest that lower plasma concentrations of PC16:0\/20:5, PC16:0\/22:6, and PC18:0\/22:6 are associated with poorer memory performance as well as widespread decreases in brain function during aging. Dysregulation of peripheral phosphatidylcholine metabolism may therefore be a common feature of both Alzheimer's disease and age-associated differences in cognition.\n                  <\/jats:p>","DOI":"10.1177\/0271678x15611678","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:48:36Z","timestamp":1449236916000},"page":"1212-1223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Blood metabolite markers of cognitive performance and brain function in aging"],"prefix":"10.1177","volume":"36","author":[{"given":"Brittany N","family":"Simpson","sequence":"first","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"},{"name":"School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Beason-Held","sequence":"additional","affiliation":[{"name":"Brain Aging and Behavior Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kitner-Triolo","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kraut","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth T","family":"Lirette","sequence":"additional","affiliation":[{"name":"Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Gwen","family":"Windham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Griswold","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Legido-Quigley","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav","family":"Thambisetty","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"bibr1-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726f5"},{"key":"bibr2-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"bibr3-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"bibr4-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"bibr5-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028092"},{"key":"bibr6-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.84"},{"key":"bibr7-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20338"},{"key":"bibr8-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.06.014"},{"key":"bibr9-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1272-0"},{"key":"bibr10-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.954941"},{"key":"bibr11-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.08.001"},{"key":"bibr12-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3466"},{"key":"bibr13-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.12.1416"},{"key":"bibr14-0271678X15611678","unstructured":"Shock NW, Greulich RC, Costa PT, et\u00a0al.\n                      Normal human aging: the Baltimore longitudinal study of aging\n                      . Washington, DC: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Aging, Gerontology Research Center, Baltimore City Hospitals, 1984."},{"key":"bibr15-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.5.464"},{"key":"bibr16-0271678X15611678","volume-title":"American Psychiatric Association. Diagnostic criteria from DSM-III-R","author":"Williams JBW","year":"1987"},{"key":"bibr17-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"bibr18-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"bibr19-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj037"},{"key":"bibr20-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.1.123"},{"key":"bibr21-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"bibr22-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"bibr23-0271678X15611678","volume-title":"The revised visual retention test","author":"Benton A","year":"1974"},{"key":"bibr24-0271678X15611678","volume-title":"Manual for kit of factor referenced cognitive tests","author":"Ekstrom RB","year":"1976"},{"key":"bibr25-0271678X15611678","volume-title":"Missile wounds of the brain","author":"Newcombe F","year":"1969"},{"key":"bibr26-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(68)90038-9"},{"key":"bibr27-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1992.tb01449.x"},{"key":"bibr28-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30932"},{"key":"bibr29-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1402-13.2013"},{"key":"bibr30-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.026"},{"key":"bibr31-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.03.025"},{"key":"bibr32-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1017"},{"key":"bibr33-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01340.x"},{"key":"bibr34-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/8.7.593"},{"key":"bibr35-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.12.013"},{"key":"bibr36-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.02.051"},{"key":"bibr37-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.04.002"},{"key":"bibr38-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1017\/S135561770171106X"},{"key":"bibr39-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1518"},{"key":"bibr40-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.03.011"},{"key":"bibr41-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.55"},{"key":"bibr42-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063644"},{"key":"bibr43-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217697"},{"key":"bibr44-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.05.013"},{"key":"bibr45-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.189"},{"key":"bibr46-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.041343"},{"key":"bibr47-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.07.019"},{"key":"bibr48-0271678X15611678","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2012.04.006"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X15611678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X15611678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X15611678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:37Z","timestamp":1777493557000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X15611678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,29]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1177\/0271678X15611678"],"URL":"https:\/\/doi.org\/10.1177\/0271678x15611678","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,29]]}}}