{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:39:51Z","timestamp":1777793991182,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Outcome varies among patients with subarachnoid hemorrhage but known prognostic factors explain only a small portion of the variation in outcome. We hypothesized that individual genetic variations influence brain and vascular responses to subarachnoid hemorrhage and investigated this using inbred strains of mice.<\/jats:p>\n                  <jats:p>Subarachnoid hemorrhage was induced in seven inbred and a chromosome 7 substitution strain of mouse. Cerebral blood flow, vasospasm of the middle cerebral artery, and brain injury were assessed. After 48\u2009h of subarachnoid hemorrhage, mice showed significant middle cerebral artery vasospasm that correlated positively with reduction in cerebral blood flow at 45\u2009min. Mice also had increased neuronal injury compared to sham controls; A\/J and C57BL\/6\u2009J strains represented the most and least severe, respectively. However, brain injury did not correlate with cerebral blood flow reduction at 45\u2009min or with vasospasm at 48\u2009h. Chromosome 7 substitution did not influence the degree of vasospasm or brain injury.<\/jats:p>\n                  <jats:p>Our data suggested that mouse genetic background influences outcome of subarachnoid hemorrhage. Investigations into the genetic factors causing these inter-strain differences may provide insight into the etiology of the brain damage following subarachnoid hemorrhage. These findings also have implications for animal modeling of disease and suggest that genetic differences may also modulate outcome in other cardiovascular diseases.<\/jats:p>","DOI":"10.1177\/0271678x15612489","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T13:47:45Z","timestamp":1449236865000},"page":"1942-1954","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Robust effects of genetic background on responses to subarachnoid hemorrhage in mice"],"prefix":"10.1177","volume":"36","author":[{"given":"Josephine A","family":"D'Abbondanza","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, St. Michael\u2019s Hospital, Toronto, ON, Canada"},{"name":"Labatt Family Centre of Excellence in Brain Injury and Trauma Research, St. Michael\u2019s Hospital, Toronto, ON, Canada"},{"name":"Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge 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