{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:01:19Z","timestamp":1793084479144,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    Receptor occupancy studies performed with PET often require time-consuming dynamic imaging for baseline and post-dose scans. Shorter protocol approximations based on standard uptake value ratios have been proposed. However, such methods depend on the time-point chosen for the quantification and often lead to overestimation and bias. The aim of this study was to develop a shorter protocol for the quantification of post-dose scans using a dual time-point approximation, which employs kinetic parameters from the baseline scan. Dual time-point was evaluated for a [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride PET dose occupancy study with the D2 antagonist JNJ-37822681, obtaining estimates for binding potential and receptor occupancy. Results were compared to standard simplified reference tissue model and standard uptake value ratios-based estimates. Linear regression and Bland\u2013Altman analysis demonstrated excellent correlation and agreement between dual time-point and the standard simplified reference tissue model approach. Moreover, the stability of dual time-point-based estimates is shown to be independent of the time-point chosen for quantification. Therefore, a dual time-point imaging protocol can be applied to post-dose [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride PET scans, resulting in a significant reduction in total acquisition time while maintaining accuracy in the quantification of both the binding potential and the receptor occupancy.\n                  <\/jats:p>","DOI":"10.1177\/0271678x16644463","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T22:30:27Z","timestamp":1460500227000},"page":"866-876","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual time-point imaging for post-dose binding potential estimation applied to a [\n                    <sup>11<\/sup>\n                    C]raclopride PET dose occupancy study"],"prefix":"10.1177","volume":"37","author":[{"given":"Isadora L","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoon TM","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi A","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria M","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Imaging, School of Physics, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Koole","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"},{"name":"Department of Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"bibr1-0271678X16644463","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.04.009"},{"key":"bibr2-0271678X16644463","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003398951"},{"key":"bibr3-0271678X16644463","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493"},{"key":"bibr4-0271678X16644463","doi-asserted-by":"crossref","unstructured":"Willemsen ATMW and Paans AMJ. 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