{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:03:41Z","timestamp":1789495421917,"version":"build-2803163510"},"reference-count":57,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Magnesium sulfate is now widely recommended for neuroprotection for preterm birth; however, this has been controversial because there is little evidence that magnesium sulfate is neuroprotective. Preterm fetal sheep (104 days gestation; term is 147 days) were randomly assigned to receive sham occlusion (n\u2009=\u20097), i.v. magnesium sulfate (n\u2009=\u200910) or saline (n\u2009=\u20098) starting 24\u2009h before asphyxia until 24\u2009h after asphyxia. Sheep were killed 72\u2009h after asphyxia. Magnesium sulfate infusion reduced electroencephalograph power and fetal movements before asphyxia. Magnesium sulfate infusion did not affect electroencephalograph power during recovery, but was associated with marked reduction of the post-asphyxial seizure burden (mean\u2009\u00b1\u2009SD: 34\u2009\u00b1\u200918\u2009min vs. 107\u2009\u00b1\u200974\u2009min, P\u2009&lt;\u20090.05). Magnesium sulfate infusion did not affect subcortical neuronal loss. In the intragyral and periventricular white matter, magnesium sulfate was associated with reduced numbers of all (Olig\u22122+ve) oligodendrocytes in the intragyral (125\u2009\u00b1\u200923 vs. 163\u2009\u00b1\u200938 cells\/field) and periventricular white matter (162\u2009\u00b1\u200939 vs. 209\u2009\u00b1\u200944 cells\/field) compared to saline-treated controls ( P\u2009&lt;\u20090.05), but no effect on microglial induction or astrogliosis. In conclusion, a clinically comparable dose of magnesium sulfate showed significant anticonvulsant effects after asphyxia in preterm fetal sheep, but did not reduce asphyxia-induced brain injury and exacerbated loss of oligodendrocytes.<\/jats:p>","DOI":"10.1177\/0271678x16655548","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T21:09:09Z","timestamp":1466197749000},"page":"1362-1373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep"],"prefix":"10.1177","volume":"37","author":[{"given":"Robert","family":"Galinsky","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"},{"name":"The Ritchie Centre, the Hudson Institute of Medical Research, Clayton, Victoria, 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