{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:28:04Z","timestamp":1790965684308,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    We examined in live coronal slices from rat and mouse which brain regions generate potassium-triggered spreading depolarization (SD\n                    <jats:sub>Kt<\/jats:sub>\n                    ). This technique simulates cortical spreading depression, which underlies migraine aura in the intact brain. An SD\n                    <jats:sub>Kt<\/jats:sub>\n                    episode was evoked by increasing bath [K\n                    <jats:sup>+<\/jats:sup>\n                    ]\n                    <jats:sub>o<\/jats:sub>\n                    and recorded as a propagating front of elevated light transmittance representing transient neuronal swelling in gray matter of neocortex, hippocampus, striatum, and thalamus. In contrast, SD\n                    <jats:sub>Kt<\/jats:sub>\n                    was not imaged in hypothalamic nuclei or brainstem with exception of those nuclei near the dorsal brainstem surface. In rat slices, single neurons were whole-cell current clamped during SD\n                    <jats:sub>Kt<\/jats:sub>\n                    . \u201cHigher\u201d neurons depolarized to near zero millivolts indicating SD\n                    <jats:sub>Kt<\/jats:sub>\n                    generation. In contrast, seven types of neurons in hypothalamus and brainstem only slowly depolarized without generating SD\n                    <jats:sub>Kt<\/jats:sub>\n                    , supporting our imaging findings. Therefore, SD\n                    <jats:sub>Kt<\/jats:sub>\n                    is not a default of CNS neurons but rather displays a region-specific susceptibility, similar to anoxic depolarization, which we have proposed is correlated with a region\u2019s vulnerability to traumatic brain injury. In the higher brain, SD\n                    <jats:sub>Kt<\/jats:sub>\n                    may be a vestigial spreading depolarization that originally evolved to shut down and vasoconstrict gray matter regions more exposed to impact and contusion.\n                  <\/jats:p>","DOI":"10.1177\/0271678x16657344","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T22:19:28Z","timestamp":1467757168000},"page":"1735-1747","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Spreading depolarization triggered by elevated potassium is weak or absent in the rodent lower brain"],"prefix":"10.1177","volume":"37","author":[{"given":"R David","family":"Andrew","sequence":"first","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Devin","family":"Brisson","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"bibr1-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1065"},{"key":"bibr2-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182886932"},{"key":"bibr3-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2333"},{"key":"bibr4-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"bibr5-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00358.x"},{"key":"bibr6-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.3.249"},{"key":"bibr7-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.1.414"},{"key":"bibr8-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00654.2004"},{"key":"bibr9-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183717"},{"key":"bibr10-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0005"},{"key":"bibr11-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654495"},{"key":"bibr12-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1947.10.6.409"},{"key":"bibr13-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.004"},{"key":"bibr14-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.2.239"},{"key":"bibr15-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044306707-5.50012-2"},{"key":"bibr16-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.11.2091"},{"key":"bibr17-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480120303"},{"key":"bibr18-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.5.0750"},{"key":"bibr19-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-21425-2_10"},{"key":"bibr20-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096585"},{"key":"bibr21-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1139\/y92-268"},{"key":"bibr22-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00081-9"},{"key":"bibr23-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01359-0"},{"key":"bibr24-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00321.2002"},{"key":"bibr25-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00201.2014"},{"key":"bibr26-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2014.05.009"},{"key":"bibr27-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028994"},{"key":"bibr28-0271678X16657344","unstructured":"Andrew RD and Brisson CD. Trauma trumps stroke: Why is our higher brain inept at dealing with blocked blood flow? In:\n                      Vasospasm 2011: The 11th international conference on neurovascular events after subarachnoid hemorrhage\n                      , 2011, pp.311\u2013312."},{"key":"bibr29-0271678X16657344","doi-asserted-by":"crossref","unstructured":"Somjen GG.\n                      Ions in the Brain\n                      . New York: Oxford University Press, 2004, p.268.","DOI":"10.1093\/oso\/9780195151718.001.0001"},{"key":"bibr30-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-005-4811-5"},{"key":"bibr31-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00437.x"},{"key":"bibr32-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00024"},{"key":"bibr33-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk032"},{"key":"bibr34-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq018"},{"key":"bibr35-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079589"},{"key":"bibr36-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00090.2012"},{"key":"bibr37-0271678X16657344","volume-title":"Program No. 449.04. Neuroscience [2012] Abstracts","author":"Andrew RD","year":"2012"},{"key":"bibr38-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00855.2011"},{"key":"bibr39-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4050"},{"key":"bibr40-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.03.004"},{"key":"bibr41-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20747"},{"key":"bibr42-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.049"},{"key":"bibr43-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90417-4"},{"key":"bibr44-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90013-W"},{"key":"bibr45-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0400-15.2015"},{"key":"bibr46-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-009-9216-y"},{"key":"bibr47-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000272"},{"key":"bibr48-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1002\/wmts.54"},{"key":"bibr49-0271678X16657344","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1081-09.2009"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16657344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X16657344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16657344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:35Z","timestamp":1777493615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X16657344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0271678X16657344"],"URL":"https:\/\/doi.org\/10.1177\/0271678x16657344","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,20]]}}}