{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:46:29Z","timestamp":1777794389133,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>A noninvasive method for quantifying cerebral blood flow and simultaneously visualizing cerebral blood flow territories is vessel-encoded pseudocontinuous arterial spin labeling MRI. However, obstacles to acquiring such information include limited access to the methodology in clinical centers and limited work on how clinically acquired vessel-encoded pseudocontinuous arterial spin labeling data correlate with gold-standard methods. The purpose of this work is to develop and validate a semiautomated pipeline for the online quantification of cerebral blood flow maps and cerebral blood flow territories from planning-free vessel-encoded pseudocontinuous arterial spin labeling MRI with gold-standard digital subtraction angiography. Healthy controls (n\u2009=\u200910) and intracranial atherosclerotic disease patients (n\u2009=\u200934) underwent 3.0\u2009T MRI imaging including vascular (MR angiography) and hemodynamic (cerebral blood flow-weighted arterial spin labeling) MRI. Patients additionally underwent catheter and\/or CT angiography. Variations in cross-territorial filling were grouped according to diameters of circle of Willis vessels in controls. In patients, Cohen\u2019s k-statistics were computed to quantify agreement in perfusion patterns between vessel-encoded pseudocontinuous arterial spin labeling and angiography. Cross-territorial filling patterns were consistent with circle of Willis anatomy. The intraobserver Cohen's k-statistics for cerebral blood flow territory and digital subtraction angiography perfusion agreement were 0.730 (95% CI\u2009=\u20090.593\u20130.867; reader one) and 0.708 (95% CI\u2009=\u20090.561\u20130.855; reader two). These results support the feasibility of a semiautomated pipeline for evaluating major neurovascular cerebral blood flow territories in patients with intracranial atherosclerotic disease.<\/jats:p>","DOI":"10.1177\/0271678x16657573","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T21:38:53Z","timestamp":1467927533000},"page":"1944-1958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Planning-free cerebral blood flow territory mapping in patients with intracranial arterial stenosis"],"prefix":"10.1177","volume":"37","author":[{"given":"Daniel F","family":"Arteaga","sequence":"first","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan K","family":"Strother","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Taylor","family":"Davis","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Fusco","sequence":"additional","affiliation":[{"name":"Neurosurgery, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos C","family":"Faraco","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A","family":"Roach","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison O","family":"Scott","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manus J","family":"Donahue","sequence":"additional","affiliation":[{"name":"Radiology, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Psychiatry, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Physics and Astronomy, Vanderbilt University, Nashville, USA"},{"name":"Neurology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"bibr1-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70195-9"},{"key":"bibr2-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"bibr3-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.224"},{"key":"bibr4-0271678X16657573","doi-asserted-by":"crossref","unstructured":"Alsop DC, Detre JA, Golay X, et\u00a0al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.\n                      Magn Reson Med\n                      2015; 73(1): 102\u2013116.","DOI":"10.1002\/mrm.25197"},{"key":"bibr5-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24872"},{"key":"bibr6-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24150"},{"key":"bibr7-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2410"},{"key":"bibr8-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.520593"},{"key":"bibr9-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1259"},{"key":"bibr10-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-004-1014-6"},{"key":"bibr11-0271678X16657573","first-page":"643","volume":"21","author":"Samuels OB","year":"2000","journal-title":"AJNR"},{"key":"bibr12-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00014"},{"key":"bibr13-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1080\/01969727308546046"},{"key":"bibr14-0271678X16657573","unstructured":"Arthur D and Vassilvitskii S. K-means++: the advantages of careful seeding. In:\n                      Proceedings of the eighteenth annual ACM-SIAM symposium on discrete algorithms.\n                      Philadelphia, PA: Society for Industrial and Applied Mathematics, 2007, pp.1027\u20131103."},{"key":"bibr15-0271678X16657573","doi-asserted-by":"crossref","unstructured":"Liebeskind DS and Caplan LR. Anatomy of Intracranial Arteries. In: Kim JS, Caplan LR and Wong KSL (eds)\n                      Intracranial Atherosclerosis\n                      . Oxford: Wiley-Blackwell, 2008.","DOI":"10.1002\/9781444300673.ch1"},{"key":"bibr16-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.3.257"},{"key":"bibr17-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2333031276"},{"key":"bibr18-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10475"},{"key":"bibr19-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000120312.26163.EC"},{"key":"bibr20-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21293"},{"key":"bibr21-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22524"},{"key":"bibr22-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2011.12.004"},{"key":"bibr23-0271678X16657573","doi-asserted-by":"crossref","unstructured":"Berry ES, Jezzard P and Okell TW. An optimized encoding scheme for planning vessel-encoded pseudocontinuous arterial spin labeling.\n                      Magn Reson Med\n                      2015; 74(5): 1248\u20131256.","DOI":"10.1002\/mrm.25508"},{"key":"bibr24-0271678X16657573","doi-asserted-by":"crossref","unstructured":"Donahue MJ, Strother MK, Lindsey KP, et al. Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays.\n                      J Cereb Blood Flow Metab\n                      . Epub ahead of print 19 October 2015. DOI: 10.1177\/0271678X15608643.","DOI":"10.1177\/0271678X15608643"},{"key":"bibr25-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.06.017"},{"key":"bibr26-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3551"},{"key":"bibr27-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3638"},{"key":"bibr28-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00293"},{"key":"bibr29-0271678X16657573","first-page":"47","volume":"70","author":"Al-Rafiah A","year":"2011","journal-title":"Folia Morphol"},{"key":"bibr30-0271678X16657573","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.514265"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16657573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X16657573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16657573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:37Z","timestamp":1777493617000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X16657573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/0271678X16657573"],"URL":"https:\/\/doi.org\/10.1177\/0271678x16657573","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,20]]}}}