{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:31Z","timestamp":1790226091060,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Of the two\n                    <jats:sup>18<\/jats:sup>\n                    F-labeled PET ligands currently available to image metabotropic glutamate receptor 5 (mGluR5), [\n                    <jats:sup>18<\/jats:sup>\n                    F]FPEB is reportedly superior because [\n                    <jats:sup>18<\/jats:sup>\n                    F]SP203 undergoes glutathionlyation, generating [\n                    <jats:sup>18<\/jats:sup>\n                    F]-fluoride ion that accumulates in brain and skull. To allow multiple PET studies on the same day with lower radiation exposure, we prepared [\n                    <jats:sup>11<\/jats:sup>\n                    C]FPEB and [\n                    <jats:sup>11<\/jats:sup>\n                    C]SP203 from [\n                    <jats:sup>11<\/jats:sup>\n                    C]hydrogen cyanide and compared their abilities to accurately quantify mGluR5 in human brain, especially as regards radiometabolite accumulation. Genomic plot was used to estimate the ratio of specific-to-nondisplaceable uptake ( BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) without using a receptor blocking drug. Both tracers quantified mGluR5; however [\n                    <jats:sup>11<\/jats:sup>\n                    C]SP203, like [\n                    <jats:sup>18<\/jats:sup>\n                    F]SP203, had radiometabolite accumulation in brain, as evidenced by increased distribution volume ( V\n                    <jats:sub>T<\/jats:sub>\n                    ) over the scan period. Absolute V\n                    <jats:sub>T<\/jats:sub>\n                    values were \u223c30% lower for\n                    <jats:sup>11<\/jats:sup>\n                    C-labeled compared with\n                    <jats:sup>18<\/jats:sup>\n                    F-labeled radioligands, likely caused by the lower specific activities (and high receptor occupancies) of the\n                    <jats:sup>11<\/jats:sup>\n                    C radioligands. The genomic plot indicated \u223c60% specific binding in cerebellum, which makes it inappropriate as a reference region. Whole-body scans performed in healthy subjects demonstrated a low radiation burden typical for\n                    <jats:sup>11<\/jats:sup>\n                    C-ligands. Thus, the evidence suggests that [\n                    <jats:sup>11<\/jats:sup>\n                    C]FPEB is superior to [\n                    <jats:sup>11<\/jats:sup>\n                    C]SP203. If prepared in higher specific activity, [\n                    <jats:sup>11<\/jats:sup>\n                    C]FPEB would presumably be as effective as [\n                    <jats:sup>18<\/jats:sup>\n                    F]FPEB for quantifying mGluR5 in human brain.\n                  <\/jats:p>","DOI":"10.1177\/0271678x16668891","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T21:38:56Z","timestamp":1473889136000},"page":"2458-2470","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of two PET radioligands, [\n                    <sup>11<\/sup>\n                    C]FPEB and [\n                    <sup>11<\/sup>\n                    C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain"],"prefix":"10.1177","volume":"37","author":[{"given":"Talakad G","family":"Lohith","sequence":"first","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tsujikawa","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice G","family":"Sim\u00e9on","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Veronese","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"},{"name":"Department of Neuroimaging, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami S","family":"Zoghbi","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hyoung","family":"Lyoo","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L","family":"Morse","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W","family":"Pike","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Innis","sequence":"additional","affiliation":[{"name":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"bibr1-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.195"},{"key":"bibr2-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.107995"},{"key":"bibr3-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.056291"},{"key":"bibr4-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.028"},{"key":"bibr5-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1447-8"},{"key":"bibr6-0271678X16668891","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1124\/jpet.108.143347","volume":"327","author":"Shetty HU","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr7-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2205-x"},{"key":"bibr8-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.135"},{"key":"bibr9-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.01.058"},{"key":"bibr10-0271678X16668891","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.162461"},{"key":"bibr11-0271678X16668891","unstructured":"Smith D. 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Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example.\n                      J Cereb Blood Flow Metab\n                      2012; 32: 70\u201380.","DOI":"10.1038\/jcbfm.2011.108"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16668891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X16668891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X16668891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:13:57Z","timestamp":1777493637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X16668891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/0271678X16668891"],"URL":"https:\/\/doi.org\/10.1177\/0271678x16668891","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}