{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:56:54Z","timestamp":1791341814276,"version":"4.3.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    The partial pressure in oxygen remains challenging to map in the brain. Two main strategies exist to obtain surrogate measures of tissue oxygenation: the tissue saturation studied by magnetic resonance imaging (S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI) and the identification of hypoxia by a positron emission tomography (PET) biomarker with 3-[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([\n                    <jats:sup>18<\/jats:sup>\n                    F]-FMISO) as the leading radiopharmaceutical. Nonetheless, a formal validation of S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI against FMISO-PET has not been performed. The objective of our studies was to compare the two approaches in (a) the normal rat brain when the rats were submitted to hypoxemia; (b) animals implanted with four tumour types differentiated by their oxygenation. Rats were submitted to normoxic and hypoxemic conditions. For the brain tumour experiments, U87-MG, U251-MG, 9L and C6 glioma cells were orthotopically inoculated in rats. For both experiments, S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI and [\n                    <jats:sup>18<\/jats:sup>\n                    F]-FMISO PET were performed sequentially. Under hypoxemia conditions, S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI revealed a decrease in oxygen saturation in the brain. Nonetheless, [\n                    <jats:sup>18<\/jats:sup>\n                    F]-FMISO PET, pimonidazole immunohistochemistry and molecular biology were insensitive to hypoxia. Within the context of tumours, S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI was able to detect hypoxia in the hypoxic models, mimicking [\n                    <jats:sup>18<\/jats:sup>\n                    F]-FMISO PET with high sensitivity\/specificity. Altogether, our data clearly support that, in brain pathologies, S\n                    <jats:sub>t<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -MRI could be a robust and specific imaging biomarker to assess hypoxia.\n                  <\/jats:p>","DOI":"10.1177\/0271678x16671965","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T21:23:17Z","timestamp":1475616197000},"page":"2584-2597","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Imaging of brain oxygenation with magnetic resonance imaging: A validation with positron emission tomography in the healthy and tumoural brain"],"prefix":"10.1177","volume":"37","author":[{"given":"Samuel","family":"Valable","sequence":"first","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, CEA, CNRS, ISTCT\/CERVOxy Group, Caen, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Divoux","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, CEA, CNRS, ISTCT\/CERVOxy Group, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Barr\u00e9","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, CEA, CNRS, ISTCT\/LDM-TEP Group, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, CEA, CNRS, ISTCT\/CERVOxy Group, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwige","family":"Petit","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, CEA, CNRS, ISTCT\/CERVOxy Group, Caen, 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