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The injured brain has limited repair capacity, and thereby only modest improvement of neurological function is evident post injury. In rodents, embryonic neural stem cells in the ventricular zone generate cortical neurons, and adult neural stem cells in the ventricular\u2013subventricular zone of the lateral ventricle produce new neurons through animal life. In addition to generation of new neurons, neural stem cells contribute to oligodendrogenesis. Neurogenesis and oligodendrogenesis are essential for repair of injured brain. Much progress has been made in preclinical studies on elucidating the cellular and molecular mechanisms that control and coordinate neurogenesis and oligodendrogenesis in perinatal hypoxic\/ischemic injury and the adult ischemic brain. This article will review these findings with a focus on the ventricular\u2013subventricular zone neurogenic niche and discuss potential applications to facilitate endogenous neurogenesis and thereby to improve neurological function post perinatal hypoxic\/ischemic injury and stroke.<\/jats:p>","DOI":"10.1177\/0271678x16674487","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T21:50:57Z","timestamp":1476481857000},"page":"2034-2043","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["Function of neural stem cells in ischemic brain repair processes"],"prefix":"10.1177","volume":"36","author":[{"given":"Ruilan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, 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