{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T16:20:44Z","timestamp":1793550044960,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia\u2013ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production. The results suggest that infection and inflammation might contribute to HI-induced energy failure.<\/jats:p>","DOI":"10.1177\/0271678x17691292","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T17:36:51Z","timestamp":1485884211000},"page":"1192-1198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic\u2013ischemic injury in the developing brain"],"prefix":"10.1177","volume":"37","author":[{"given":"Amin","family":"Mottahedin","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Svedin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syam","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Johan","family":"Mohn","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK"},{"name":"Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Ek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"bibr1-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058834"},{"key":"bibr2-0271678X17691292","first-page":"e030269","volume":"3","author":"Antonucci R","year":"2014","journal-title":"J Pediat Neonat Indiv Med"},{"key":"bibr3-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1772"},{"key":"bibr4-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.13"},{"key":"bibr5-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70710-8"},{"key":"bibr6-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.007"},{"key":"bibr7-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80119-3"},{"key":"bibr8-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.19.2357"},{"key":"bibr9-0271678X17691292","first-page":"297\u2013305","volume":"101","author":"Mottahedin A","year":"2016","journal-title":"J Leukocyte Biol"},{"key":"bibr10-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0673-13.2013"},{"key":"bibr11-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07525.x"},{"key":"bibr12-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"bibr13-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.02.003"},{"key":"bibr14-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019583"},{"key":"bibr15-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-45"},{"key":"bibr16-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01474.x"},{"key":"bibr17-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003428"},{"key":"bibr18-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.05.009"},{"key":"bibr19-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800152105"},{"key":"bibr20-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000163513.03619.8D"},{"key":"bibr21-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12723"},{"key":"bibr22-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70261-8"},{"key":"bibr23-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04327.x"},{"key":"bibr24-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000525"},{"key":"bibr25-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.09.011"},{"key":"bibr26-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.144"},{"key":"bibr27-0271678X17691292","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00107-2"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X17691292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X17691292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X17691292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:14:20Z","timestamp":1777493660000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X17691292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/0271678X17691292"],"URL":"https:\/\/doi.org\/10.1177\/0271678x17691292","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}