{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:10:00Z","timestamp":1790615400418,"version":"4.1.0"},"reference-count":67,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Cerebral blood flow (CBF) is regulated to secure brain O\n                    <jats:sub>2<\/jats:sub>\n                    delivery while simultaneously avoiding hyperperfusion; however, both requisites may conflict during sprint exercise. To determine whether brain O\n                    <jats:sub>2<\/jats:sub>\n                    delivery or CBF is prioritized, young men performed sprint exercise in normoxia and hypoxia (P\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u200973\u2009mmHg). During the sprints, cardiac output increased to \u223c22 L\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    , mean arterial pressure to \u223c131\u2009mmHg and peak systolic blood pressure ranged between 200 and 304\u2009mmHg. Middle-cerebral artery velocity (MCAv) increased to peak values (\u223c16%) after 7.5\u2009s and decreased to pre-exercise values towards the end of the sprint. When the sprints in normoxia were preceded by a reduced P\n                    <jats:sub>ET<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    , CBF and frontal lobe oxygenation decreased in parallel ( r\u2009=\u20090.93, P\u2009&lt;\u20090.01). In hypoxia, MCAv was increased by 25%, due to a 26% greater vascular conductance, despite 4\u20136\u2009mmHg lower PaCO\n                    <jats:sub>2<\/jats:sub>\n                    in hypoxia than normoxia. This vasodilation fully accounted for the 22 % lower CaO\n                    <jats:sub>2<\/jats:sub>\n                    in hypoxia, leading to a similar brain O\n                    <jats:sub>2<\/jats:sub>\n                    delivery during the sprints regardless of P\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . In conclusion, when a conflict exists between preserving brain O\n                    <jats:sub>2<\/jats:sub>\n                    delivery or restraining CBF to avoid potential damage by an elevated perfusion pressure, the priority is given to brain O\n                    <jats:sub>2<\/jats:sub>\n                    delivery.\n                  <\/jats:p>","DOI":"10.1177\/0271678x17691986","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T10:38:13Z","timestamp":1486723093000},"page":"136-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":76,"title":["Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans"],"prefix":"10.1177","volume":"38","author":[{"given":"David","family":"Curtelin","sequence":"first","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences 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Palmas de Gran Canaria, Canary Islands, Spain"},{"name":"Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Siebenmann","sequence":"additional","affiliation":[{"name":"Center for Integrative Human Physiology, Institute of Physiology, University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"P\u00e9rez-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain"},{"name":"Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 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