{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:41:43Z","timestamp":1785937303086,"version":"3.56.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) and play a detrimental effect on clinical severity and hemorrhagic transformation of the ischemic brain lesion. Using data from the Italian multicenter observational MAGIC (MArker bioloGici nell\u2019Ictus Cerebrale) Study, we evaluated the effect of inflammatory and metalloproteinases profiles on three-month functional outcome, hemorrhagic transformation and mortality in 327 patients with AIS treated with intravenous thrombolys in according to SITS-MOST (Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy) criteria. Circulating biomarkers were assessed at baseline and 24\u2009h after thrombolysis. Adjusting for age, sex, baseline glycemia and National Institute of Health Stroke Scale, history of atrial fibrillation or congestive heart failure, and of inflammatory diseases or infections, baseline alpha-2macroglobulin (A2M), baseline serum amyloid protein (SAP) and pre-post tissue-plasminogen activator (tPA) variations (\u0394) of metalloproteinase 9, remained significantly and independently associated with three-month death [OR (95% CI):A2M:2.99 (1.19\u20137.53); SAP:5.46 (1.64\u201318.74); \u0394metalloproteinase 9:1.60 (1.12\u20132.27)]. The addition of baseline A2M and \u0394metalloproteinase 9 or baseline SAP and \u0394metalloproteinase 9 (model-2 or model-3) to clinical variables (model-1) significantly improved the area under curve for prediction of death [model-2 with A2M: p\u2009=\u20090.0205; model-3 with SAP: p\u2009=\u20090.001]. In conclusion, among AIS patients treated with thrombolysis, circulating A2M, SAP and \u0394metalloproteinase 9 are independent markers of poor outcome. These results may prompt controlled clinical research about agents antagonizing their effect.<\/jats:p>","DOI":"10.1177\/0271678x17695572","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T11:11:55Z","timestamp":1488885115000},"page":"3253-3261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis"],"prefix":"10.1177","volume":"37","author":[{"given":"Anna Maria","family":"Gori","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy"},{"name":"Don Gnocchi Foundation, IRCCS, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betti","family":"Giusti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Piccardi","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Nencini","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mascia","family":"Nesi","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Nucera","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pracucci","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolina","family":"Tonelli","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Sereni","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sticchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Toni","sequence":"additional","affiliation":[{"name":"Emergency Department Stroke Unit and Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bovi","sequence":"additional","affiliation":[{"name":"DAI di Neuroscienze, Azienda Ospedaliera Integrata, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Guidotti","sequence":"additional","affiliation":[{"name":"Neurology Unit, Valduce General Hospital, Como, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Tola","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Consoli","sequence":"additional","affiliation":[{"name":"U.O. Neurologia, G. Jazzolino Hospital, Vibo Valentia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Micieli","sequence":"additional","affiliation":[{"name":"Istituto Neurologico Nazionale C. Mondino, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Tassi","sequence":"additional","affiliation":[{"name":"U.O.C. 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