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Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and\/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence\/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.<\/jats:p>","DOI":"10.1177\/0271678x17700432","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T06:32:31Z","timestamp":1489732351000},"page":"2314-2319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":93,"title":["Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering"],"prefix":"10.1177","volume":"37","author":[{"given":"Joshua D","family":"Bernstock","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK"},{"name":"Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes 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