{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:56:13Z","timestamp":1783612573719,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>We investigated the effect of Rho kinase inhibition on changes in cerebral blood flow (CBF), brain injury and vascular function after ischemic stroke in spontaneously hypertensive rats (SHR). Changes in core MCA and collateral perfusion were measured by a validated laser Doppler method. Animals underwent 2\u2009h tMCAO and 2\u2009h reperfusion. Fasudil (0.1\u2009mg\/kg, i.v.) or vehicle was given at 30\u2009min ischemia (n\u2009=\u20099\/group; mean (SD)). Brain injury was determined by 2,3,5-triphenyltetrazolium chloride staining. To determine the effect of fasudil on vascular function, fasudil was given 10\u2009min before reperfusion and parenchymal arterioles studied isolated (n\u2009=\u20096\/group; mean(SD)). Collateral perfusion was low in vehicle-treated SHR (\u22128(32)%) that changed minimally with fasudil (6(24)%, p\u2009&gt;\u20090.05, effect size: 0.47;95% CI\u22120.49\u20131.39). Reperfusion CBF was below baseline in vehicle (\u221227(26)%) and fasudil (\u221232(25)%, p\u2009&gt;\u20090.05, effect size: 0.19; 95% CI\u22120.74\u20131.11) groups, suggesting incomplete reperfusion in both groups. Fasudil had little effect on brain injury volume (28(13)% vs. 36(7)% in vehicle, p\u2009&gt;\u20090.05, effect size: 0.75; 95% CI\u22120.24\u20131.66). In isolated parenchymal arterioles, myogenic tone was similar between groups (37(6)% vs. 38(10)% in vehicle, p\u2009&gt;\u20090.05, effect size: 0.09; 95% CI\u22121.05\u20131.21). There were no differences with fasudil treatment vs. vehicle in perfusion, brain injury and vascular function that may be related to the low dose that had minimal blood pressure lowering effect.<\/jats:p>","DOI":"10.1177\/0271678x17718665","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T10:27:54Z","timestamp":1499423274000},"page":"3262-3270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment with low dose fasudil for acute ischemic stroke in chronic hypertension"],"prefix":"10.1177","volume":"37","author":[{"given":"Siu-Lung","family":"Chan","sequence":"first","affiliation":[{"name":"Departments of Neurological Sciences, Obstetrics, Gynecology & Reproductive Sciences, and Pharmacology, Larner, College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Departments of Neurological Sciences, Obstetrics, Gynecology & Reproductive Sciences, and Pharmacology, Larner, College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"bibr1-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.3.312"},{"key":"bibr2-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60834-3"},{"key":"bibr3-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014509.11540.66"},{"key":"bibr4-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510321"},{"key":"bibr5-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000105052.65787.35"},{"key":"bibr6-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.118"},{"key":"bibr7-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.559021"},{"key":"bibr8-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2230-0"},{"key":"bibr9-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.03.031"},{"key":"bibr10-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.12.2.89"},{"key":"bibr11-0271678X17718665","first-page":"H1435","volume":"253","author":"Mayhan WG","year":"1987","journal-title":"Am J Physiol"},{"key":"bibr12-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00467.2015"},{"key":"bibr13-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013392"},{"key":"bibr14-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015465.73933.3B"},{"key":"bibr15-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.096541"},{"key":"bibr16-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1038\/40187"},{"key":"bibr17-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5272.245"},{"key":"bibr18-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000059987.90200.44"},{"key":"bibr19-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005888"},{"key":"bibr20-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01104.2004"},{"key":"bibr21-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1161\/hh0801.090441"},{"key":"bibr22-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15621069"},{"key":"bibr23-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00554.2002"},{"key":"bibr24-0271678X17718665","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01012.2004"},{"key":"bibr25-0271678X17718665","doi-asserted-by":"crossref","unstructured":"Cipolla MJ, Linfante I, Abuchowski A, et\u00a0al. Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate\u2122) in spontaneously hypertensive rats.\n                      J Cereb Blood Flow Metab\n                      . Epub ahead of print 24 April 2017. DOI: 10.1177\/0271678X17705567.","DOI":"10.1177\/0271678X17705567"},{"key":"bibr26-0271678X17718665","doi-asserted-by":"crossref","unstructured":"Cuccione E, Versace A, Cho TH, et\u00a0al. 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