{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:05:18Z","timestamp":1792253118108,"version":"4.4.0"},"reference-count":76,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Elucidating metabolic effects of hypoxic-ischaemic encephalopathy (HIE) may reveal early biomarkers of injury and new treatment targets. This study uses untargeted metabolomics to examine early metabolic alterations in a carefully defined neonatal population. Infants with perinatal asphyxia who were resuscitated at birth and recovered (PA group), those who developed HIE (HIE group) and healthy controls were all recruited at birth. Metabolomic analysis of cord blood was performed using direct infusion FT-ICR mass spectrometry. For each reproducibly detected metabolic feature, mean fold differences were calculated HIE vs. controls (\u0394HIE) and PA vs. controls (\u0394PA). Putative metabolite annotations were assigned and pathway analysis was performed. Twenty-nine putatively annotated metabolic features were significantly different in \u0394PA after false discovery correction ( q\u2009&lt;\u20090.05), with eight of these also significantly altered in \u0394HIE. Altered putative metabolites included; melatonin, leucine, kynurenine and 3-hydroxydodecanoic acid which differentiated between infant groups (\u0394PA and \u0394HIE); and D-erythrose-phosphate, acetone, 3-oxotetradecanoic acid and methylglutarylcarnitine which differentiated across severity grades of HIE. Pathway analysis revealed \u0394HIE was associated with a 50% and 75% perturbation of tryptophan and pyrimidine metabolism, respectively. We have identified perturbed metabolic pathways and potential biomarkers specific to PA and HIE, which measured at birth, may help direct treatment.<\/jats:p>","DOI":"10.1177\/0271678x17726502","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T07:06:20Z","timestamp":1503644780000},"page":"147-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy"],"prefix":"10.1177","volume":"39","author":[{"given":"Niamh M","family":"Denihan","sequence":"first","affiliation":[{"name":"Neonatal Brain Research Group, University College Cork, Cork, Ireland"},{"name":"Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-1651","authenticated-orcid":false,"given":"Jennifer A","family":"Kirwan","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA"},{"name":"Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick B","family":"Dunn","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Birmingham, Birmingham, UK"},{"name":"Phenome Centre Birmingham, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I","family":"Broadhurst","sequence":"additional","affiliation":[{"name":"School of Science, Edith Cowan University, Joondalup, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B","family":"Boylan","sequence":"additional","affiliation":[{"name":"Neonatal Brain Research Group, University College Cork, Cork, Ireland"},{"name":"Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M","family":"Murray","sequence":"additional","affiliation":[{"name":"Neonatal Brain Research Group, University College Cork, Cork, Ireland"},{"name":"Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"bibr1-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"bibr2-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.047985"},{"key":"bibr3-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.206"},{"key":"bibr4-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315788"},{"key":"bibr5-0271678X17726502","first-page":"Cd003311","volume":"1","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1159\/000353948"},{"key":"bibr7-0271678X17726502","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1524"},{"key":"bibr8-0271678X17726502","doi-asserted-by":"crossref","unstructured":"Volpe JJ. 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