{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:23:56Z","timestamp":1791483836145,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort ( n\u2009=\u2009702, age range 60 \u2013 82 years, mean age\u2009=\u200969.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter\u2014including the corticospinal tract\u2014compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.<\/jats:p>","DOI":"10.1177\/0271678x17740501","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T10:13:59Z","timestamp":1509963239000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":165,"title":["Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly"],"prefix":"10.1177","volume":"39","author":[{"given":"Leonie","family":"Lampe","sequence":"first","affiliation":[{"name":"Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Clinic of Cognitive Neurology, University Hospital Leipzig, Leipzig, 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