{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:08:08Z","timestamp":1790456888242,"version":"4.1.0"},"reference-count":96,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates a myriad of homeostatic and stress responses. The SUMOylation pathway has been extensively studied in brain ischemia. Convincing evidence is now at hand to support the notion that a major increase in levels of SUMOylated proteins is capable of inducing tolerance to ischemic stress. Therefore, the SUMOylation pathway has emerged as a promising therapeutic target for neuroprotection in the face of brain ischemia. Despite this, it is prudent to acknowledge that there are many key questions still to be addressed in brain ischemia related to SUMOylation. Accordingly, herein, we provide a critical review of literature within the field to summarize current knowledge and in so doing highlight pertinent translational implications of the SUMOylation pathway in brain ischemia.<\/jats:p>","DOI":"10.1177\/0271678x17742260","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T06:01:56Z","timestamp":1510898516000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["SUMOylation in brain ischemia: Patterns, targets, and translational implications"],"prefix":"10.1177","volume":"38","author":[{"given":"Joshua D","family":"Bernstock","sequence":"first","affiliation":[{"name":"Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS\/NIH), Bethesda, MD, USA"},{"name":"Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G","family":"Ye","sequence":"additional","affiliation":[{"name":"Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS\/NIH), Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pluchino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Ja","family":"Lee","sequence":"additional","affiliation":[{"name":"Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS\/NIH), Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Hallenbeck","sequence":"additional","affiliation":[{"name":"Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS\/NIH), Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulf","family":"Paschen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA"},{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"bibr1-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600395"},{"key":"bibr2-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15608393"},{"key":"bibr3-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600601"},{"key":"bibr4-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600523"},{"key":"bibr5-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004315"},{"key":"bibr6-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201438534"},{"key":"bibr7-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.038570"},{"key":"bibr8-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00651-08"},{"key":"bibr9-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1846"},{"key":"bibr10-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1101\/gad.545110"},{"key":"bibr11-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2014"},{"key":"bibr12-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3011"},{"key":"bibr13-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061909-093311"},{"key":"bibr14-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.05.002"},{"key":"bibr15-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3478"},{"key":"bibr16-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.04.016"},{"key":"bibr17-0271678X17742260","first-page":"139","volume":"1863","author":"Mendes AV","year":"2016","journal-title":"BBA Molec Cell Res"},{"key":"bibr18-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.3"},{"key":"bibr19-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.125"},{"key":"bibr20-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2293"},{"key":"bibr21-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.09.010"},{"key":"bibr22-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.11.036"},{"key":"bibr23-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.180"},{"key":"bibr24-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.26"},{"key":"bibr25-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90003-6"},{"key":"bibr26-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(95)00071-2"},{"key":"bibr27-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200206000-00009"},{"key":"bibr28-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000282"},{"key":"bibr29-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595371"},{"key":"bibr30-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3174"},{"key":"bibr31-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.16"},{"key":"bibr32-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07916.x"},{"key":"bibr33-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.2174\/1871527316666170320150659"},{"key":"bibr34-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301184"},{"key":"bibr35-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00416"},{"key":"bibr36-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05957.x"},{"key":"bibr37-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.112"},{"key":"bibr38-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025852"},{"key":"bibr39-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012514"},{"key":"bibr40-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.65"},{"key":"bibr41-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.146"},{"key":"bibr42-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8257-7"},{"key":"bibr43-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092194"},{"key":"bibr44-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.6.4021"},{"key":"bibr45-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.021"},{"key":"bibr46-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001484"},{"key":"bibr47-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.5"},{"key":"bibr48-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.021"},{"key":"bibr49-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.08.011"},{"key":"bibr50-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.06.013"},{"key":"bibr51-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016579"},{"key":"bibr52-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17723783"},{"key":"bibr53-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12347"},{"key":"bibr54-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.03.011"},{"key":"bibr55-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26338"},{"key":"bibr56-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1021\/pr200834f"},{"key":"bibr57-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0360"},{"key":"bibr58-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.607705"},{"key":"bibr59-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.04.002"},{"key":"bibr60-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8229"},{"key":"bibr61-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15609939"},{"key":"bibr62-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047787"},{"key":"bibr63-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2015.03.001"},{"key":"bibr64-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2016-000031"},{"key":"bibr65-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1177\/1087057113479971"},{"key":"bibr66-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13643"},{"key":"bibr67-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.01.009"},{"key":"bibr68-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2009.10"},{"key":"bibr69-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.142"},{"key":"bibr70-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.04.001"},{"key":"bibr71-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1021\/cb400630z"},{"key":"bibr72-0271678X17742260","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1177\/2472555216683937","volume":"22","author":"Zlotkowski K","year":"2017","journal-title":"SLAS Discov"},{"key":"bibr73-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.016"},{"key":"bibr74-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.04.008"},{"key":"bibr75-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210216"},{"key":"bibr76-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0538"},{"key":"bibr77-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212728"},{"key":"bibr78-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1415"},{"key":"bibr79-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-211045"},{"key":"bibr80-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12047"},{"key":"bibr81-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07631-9"},{"key":"bibr82-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.391441"},{"key":"bibr83-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611041200"},{"key":"bibr84-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039606"},{"key":"bibr85-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12326"},{"key":"bibr86-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.002"},{"key":"bibr87-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23563"},{"key":"bibr88-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1038\/srep09011"},{"key":"bibr89-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0331"},{"key":"bibr90-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00291"},{"key":"bibr91-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17700432"},{"key":"bibr92-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1186\/s41016-016-0054-3"},{"key":"bibr93-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.003"},{"key":"bibr94-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.10.007"},{"key":"bibr95-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130148"},{"key":"bibr96-0271678X17742260","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8797-3"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X17742260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X17742260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X17742260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:13Z","timestamp":1777493713000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X17742260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,17]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1177\/0271678X17742260"],"URL":"https:\/\/doi.org\/10.1177\/0271678x17742260","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,17]]}}}