{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:43:19Z","timestamp":1793392999433,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Cerebral hyperperfusion syndrome (CHS) is a serious complication following carotid artery stenting (CAS), but definitive early prediction of CHS has not been established. Here, we evaluated whether indocyanine green kinetics and near-infrared spectroscopy (ICG-NIRS) with hyperventilation (HV) and the breath-holding (BH) test can predict hyperperfusion phenomenon after CAS. The blood flow index (BFI) ratio during HV and BH was prospectively monitored using ICG-NIRS in 66 patients scheduled to undergo CAS. Preoperative cerebrovascular reactivity (CVR) and the postoperative asymmetry index (AI) were also assessed with single-photon emission computed tomography before and after CAS and the correlation with the BFI HV\/rest ratio, BFI BH\/rest ratio was evaluated. Twelve cases (18%) showed hyperperfusion phenomenon, and one (1.5%) showed CHS after CAS. A significant linear correlation was observed between the BFI HV\/rest ratio, BFI BH\/rest ratio, and preoperative CVR. A significant linear correlation was observed between the BFI HV\/rest ratio and postoperative AI (r\u2009=\u20090.674, P\u2009&lt;\u20090.0001). A BFI HV\/rest ratio of 0.88 or more was the optimal cut-off point to predict hyperperfusion phenomenon according to receiver operating characteristic curve analyses. HV and BH test under ICG-NIRS is a useful tool for detection of hyperperfusion phenomenon in patients who underwent CAS.<\/jats:p>","DOI":"10.1177\/0271678x17743878","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T09:34:54Z","timestamp":1510911294000},"page":"901-912","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperventilation and breath-holding test with indocyanine green kinetics predicts cerebral hyperperfusion after carotid artery stenting"],"prefix":"10.1177","volume":"39","author":[{"given":"Ichiro","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Wajima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Motoyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Su","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Kichikawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"bibr1-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000068781.31429.BE"},{"key":"bibr2-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.07.018"},{"key":"bibr3-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112618"},{"key":"bibr4-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000244807.99073.ae"},{"key":"bibr5-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.4.477"},{"key":"bibr6-0271678X17743878","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199804000-00013"},{"key":"bibr7-0271678X17743878","doi-asserted-by":"crossref","unstructured":"Nakagawa I, Park HS, Yokoyama S, et\u00a0al. 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