{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:56:08Z","timestamp":1777794968256,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Hypoxic-ischemic encephalopathy (HIE) is a severe neonatal complication responsible for \u223c23% of all neonatal deaths. Also, 30\u201370% of these patients will suffer lifetime disabilities, including learning impairment, epilepsy or cerebral palsy. However, biomarkers for HIE screening, or monitoring disease progression are limited. Herein, we sought to evaluate the clinical usefulness of plasma-type gelsolin (pGSN) and amyloid-beta (A\u03b2) 40 and 42 as prognostic biomarkers for HIE. pGSN has been previously suggested as a feasible marker in other brain injuries and amyloid-beta 40 and 42 are classically assessed in neurodegenerative diseases. However, to our knowledge, they have not been previously assessed in HIE patients. We have analyzed plasma pGSN and A\u03b2 40 and 42 levels in 55 newborns (16 controls, 16 mild and 23 moderate-severe HIE) at birth, during 72\u2009h of therapeutic hypothermia, a gold-standard treatment for HIE, and 24\u2009h after hypothermia. A\u03b2 levels were lower in HIE patients, and pGSN levels were progressively reduced in mild and moderate-severe HIE patients. The fact that pGSN reductions could predict the severity of HIE and significantly correlated with the time to undergo hypothermia supports the prognostic value of plasmatic pGSN. Further studies are warranted to investigate the role of pGSN in neonatal HIE.<\/jats:p>","DOI":"10.1177\/0271678x18757419","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T02:56:52Z","timestamp":1519268212000},"page":"1349-1354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Altered plasma-type gelsolin and amyloid-\u03b2 in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia"],"prefix":"10.1177","volume":"39","author":[{"given":"Isabel","family":"Benavente-Fernandez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Neonatology Unit, Puerta del Mar University Hospital, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J","family":"Ramos-Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Physiology, School of Medicine, Instituto de Investigaci\u00f3n Biomedica de Cadiz (INIBICA), Universidad de Cadiz, Cadiz, Spain"},{"name":"Salus Infirmorum, Universidad de Cadiz, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Infante-Garcia","sequence":"additional","affiliation":[{"name":"Division of Physiology, School of Medicine, Instituto de Investigaci\u00f3n Biomedica de Cadiz (INIBICA), Universidad de Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Jimenez-Gomez","sequence":"additional","affiliation":[{"name":"Research Unit, Puerta del Mar University Hospital, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Lechuga-Sancho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Unit, Puerta del Mar University Hospital, Cadiz, Spain"},{"name":"Department of Mother and Child Health and Radiology, Universidad de Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lubian-Lopez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Unit, Puerta del Mar University Hospital, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-4114","authenticated-orcid":false,"given":"Monica","family":"Garcia-Alloza","sequence":"additional","affiliation":[{"name":"Division of Physiology, School of Medicine, Instituto de Investigaci\u00f3n Biomedica de Cadiz (INIBICA), Universidad de Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"bibr1-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00144"},{"key":"bibr2-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"bibr3-0271678X18757419","first-page":"645","volume":"1","author":"Jacobs SE","year":"2013","journal-title":"Eur J Pediatr"},{"key":"bibr4-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.130"},{"key":"bibr5-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.631135"},{"key":"bibr6-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.11.031"},{"key":"bibr7-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12391"},{"key":"bibr8-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00029.2003"},{"key":"bibr9-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140966"},{"key":"bibr10-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"bibr11-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"bibr12-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1202-5"},{"key":"bibr13-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0107"},{"key":"bibr14-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1571319"},{"key":"bibr15-0271678X18757419","doi-asserted-by":"crossref","DOI":"10.1016\/j.anpedi.2011.07.013","volume":"75","author":"Blanco D","year":"2011","journal-title":"An Pediatr"},{"key":"bibr16-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100279"},{"key":"bibr17-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-3-13"},{"key":"bibr18-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2013.10.008"},{"key":"bibr19-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318226ec39"},{"key":"bibr20-0271678X18757419","doi-asserted-by":"crossref","unstructured":"Peddada N, Sagar A, Ashish, ret al. Plasma gelsolin: a general prognostic marker of health.\n                      Med Hypotheses\n                      2012; 78: 203\u2013210.","DOI":"10.1016\/j.mehy.2011.10.024"},{"key":"bibr21-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1186\/cc13178"},{"key":"bibr22-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt162"},{"key":"bibr23-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-014-1087-9"},{"key":"bibr24-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-014-1060-7"},{"key":"bibr25-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111203"},{"key":"bibr26-0271678X18757419","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161591"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X18757419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X18757419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X18757419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:27Z","timestamp":1777493727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X18757419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/0271678X18757419"],"URL":"https:\/\/doi.org\/10.1177\/0271678x18757419","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}