{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:15:42Z","timestamp":1789740942702,"version":"4.0.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    The present study examined whether preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with development of cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease. Among 65 adult patients with ischemic moyamoya disease, 19 had misery perfusion in the precentral region on preoperative\n                    <jats:sup>15<\/jats:sup>\n                    O positron emission tomography and underwent arterial bypass surgery for that region. Brain technetium-99\u2009m-labeled ethyl cysteinate dimer single-photon emission computed tomography (SPECT) was preoperatively performed with and without hyperventilation challenge and relative cerebrovascular contractile reactivity to hypocapnia (RCVCR\n                    <jats:sub>hypocap<\/jats:sub>\n                    ) (%\/mmHg) was calculated in the precentral region. Development of cerebral hyperperfusion syndrome was determined using perioperative changes of symptoms and brain N-isopropyl-p-[\n                    <jats:sup>123<\/jats:sup>\n                    I]-iodoamphetamine SPECT performed after surgery. RCVCR\n                    <jats:sub>hypocap<\/jats:sub>\n                    was significantly lower in the 6 patients with cerebral hyperperfusion syndrome (\u22122.85\u2009\u00b1\u20091.10%\/mmHg) than in the 13 patients without cerebral hyperperfusion syndrome (0.18\u2009\u00b1\u20091.97%\/mmHg; p\u2009=\u20090.0050). Multivariate analysis demonstrated low RCVCR\n                    <jats:sub>hypocap<\/jats:sub>\n                    as an independent predictor of cerebral hyperperfusion syndrome (95% confidence interval, 0.04\u20130.96; p\u2009=\u20090.0433). Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with development of cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease.\n                  <\/jats:p>","DOI":"10.1177\/0271678x18757621","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T07:03:27Z","timestamp":1517382207000},"page":"1021-1031","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease"],"prefix":"10.1177","volume":"38","author":[{"given":"Shinpei","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Iwate Medical University, Morioka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Iwate Medical University, Morioka, Japan"},{"name":"Cyclotron Research Center, School of Medicine, Iwate Medical University, Morioka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Iwate Medical University, Morioka, Japan"},{"name":"Cyclotron Research Center, School of Medicine, Iwate Medical University, Morioka, 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