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Here we find that the expression of the AAA\u2009+\u2009ATPase Thorase is induced by preconditioning stimulation both in vitro and in vivo. Thorase provides neuroprotection in an ATP-dependent manner against oxygen\u2013glucose deprivation (OGD) neurotoxicity or glutamate N-Methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in vitro. Knock-down of Thorase prevents the establishment of preconditioning induced neuroprotection against OGD or NMDA neurotoxicity. Transgenic overexpression of Thorase provides neuroprotection in vivo against middle cerebral artery occlusion (MCAO)-induced stroke in mice, while genetic deletion of Thorase results in increased injury in vivo following stroke. These results define Thorase as a neuroprotective protein and understanding Thorase signaling could offer a new therapeutic strategy for the treatment of neurologic disorders.<\/jats:p>","DOI":"10.1177\/0271678x18769770","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T06:46:01Z","timestamp":1523861161000},"page":"1836-1848","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The AAA\u2009+\u2009ATPase Thorase is neuroprotective against ischemic injury"],"prefix":"10.1177","volume":"39","author":[{"given":"Jianmin","family":"Zhang","sequence":"first","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-4357","authenticated-orcid":false,"given":"Huaishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Sherbini","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Keuss","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George KE","family":"Umanah","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily Ling-Lin","family":"Pai","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikai","family":"Chi","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa MA","family":"Paldanius","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"},{"name":"Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Solomon H. 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