{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:02:36Z","timestamp":1790085756694,"version":"4.0.1"},"reference-count":64,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Oxygen extraction (OEF), oxidative metabolism (CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ), and blood flow (CBF) in the brain, as well as the coupling between CMRO\n                    <jats:sub>2<\/jats:sub>\n                    and CBF due to cerebral autoregulation are fundamental to brain's health. We used a clinically feasible MRI protocol to assess impairments of these parameters in the perfusion territories of stenosed carotid arteries. Twenty-nine patients with unilateral high-grade carotid stenosis and thirty age-matched healthy controls underwent multi-modal MRI scans. Pseudo-continuous arterial spin labeling (pCASL) yielded absolute CBF, whereas multi-parametric quantitative blood oxygenation level dependent (mqBOLD) modeling allowed imaging of relative OEF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    . Both CBF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    were significantly reduced in the stenosed territory compared to the contralateral side, while OEF was evenly distributed across both hemispheres similarly in patients and controls. The CMRO\n                    <jats:sub>2<\/jats:sub>\n                    -CBF coupling was significantly different between both hemispheres in patients, i.e. significant interhemispheric flow-metabolism uncoupling was observed in patients compared to controls. Given that CBF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    are intimately linked to brain function in health and disease, the proposed easily applicable MRI protocol of pCASL and mqBOLD imaging might serve as a valuable tool for early diagnosis of potentially harmful cerebral hemodynamic and metabolic states with the final aim to select clinically asymptomatic patients who would benefit from carotid revascularization therapy.\n                  <\/jats:p>","DOI":"10.1177\/0271678x18783369","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T05:11:26Z","timestamp":1530594686000},"page":"2132-2143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Flow-metabolism uncoupling in patients with asymptomatic unilateral carotid artery stenosis assessed by multi-modal magnetic resonance imaging"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-2156","authenticated-orcid":false,"given":"Jens","family":"G\u00f6ttler","sequence":"first","affiliation":[{"name":"Department of Radiology & Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, USA"},{"name":"Department of Diagnostic and Interventional Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-7012","authenticated-orcid":false,"given":"Stephan","family":"Kaczmarz","sequence":"additional","affiliation":[{"name":"Department of Radiology & Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, USA"},{"name":"Department of Diagnostic and Interventional Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kallmayer","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Wustrow","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sorg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"Department of Psychiatry, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-1928","authenticated-orcid":false,"given":"Christine","family":"Preibisch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"},{"name":"Clinic for Neurology, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmeed","family":"Hyder","sequence":"additional","affiliation":[{"name":"Department of Radiology & 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