{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:25:00Z","timestamp":1789593900613,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Accumulation of amyloid beta can be visualized using [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir uptake and to assess test\u2013retest reliability of corresponding outcome measures. Eight Alzheimer\u2019s disease patients (age: 67\u2009\u00b1\u20096 years, Mini-Mental State Examination (MMSE): 23\u2009\u00b1\u20093) and eight controls (age: 63\u2009\u00b1\u20094 years, MMSE: 30\u2009\u00b1\u20090) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294\u2009\u00b1\u200932 MBq [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer\u2019s disease patients had lower MMSE scores and evidence for cortical A\u03b2 pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_V\n                    <jats:sub>B<\/jats:sub>\n                    ) was the preferred model for describing [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir kinetics. SRTM-derived non-displaceable binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) correlated well (r\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u20090.83, slope\u2009=\u20090.86) with plasma input-derived distribution volume ratio. Test\u2013retest reliability for plasma input-derived distribution volume ratio, SRTM-derived BP\n                    <jats:sub>ND<\/jats:sub>\n                    and SUVr\n                    <jats:sub>(50\u201370)<\/jats:sub>\n                    were r\u2009=\u20090.88, r\u2009=\u20090.91 and r\u2009=\u20090.86, respectively. In\u00a0vivo kinetics of [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir could best be described by a reversible two-tissue compartmental model and [\n                    <jats:sup>18<\/jats:sup>\n                    F]florbetapir BP\n                    <jats:sub>ND<\/jats:sub>\n                    can be reliably estimated using an SRTM.\n                  <\/jats:p>","DOI":"10.1177\/0271678x18783628","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T05:10:25Z","timestamp":1528866625000},"page":"2172-2180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Quantification of [\n                    <sup>18<\/sup>\n                    F]florbetapir: A test\u2013retest tracer kinetic modelling study"],"prefix":"10.1177","volume":"39","author":[{"given":"Sandeep SV","family":"Golla","sequence":"first","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander CJ","family":"Verfaillie","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Boellaard","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Nuclear Medicine & Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie M","family":"Adriaanse","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa D","family":"Zwan","sequence":"additional","affiliation":[{"name":"Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Schuit","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Timmers","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schober","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Epidemiology & Biostatistics, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D","family":"Windhorst","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart NM","family":"van Berckel","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A","family":"Lammertsma","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"bibr1-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"bibr2-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0228-4"},{"key":"bibr3-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"bibr4-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"bibr5-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"bibr6-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"bibr7-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt195"},{"key":"bibr8-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.090340"},{"key":"bibr9-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.069088"},{"key":"bibr10-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.148981"},{"key":"bibr11-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.149732"},{"key":"bibr12-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.055"},{"key":"bibr13-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0172-3"},{"key":"bibr14-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.113654"},{"key":"bibr15-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.139121"},{"key":"bibr16-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3696-1"},{"key":"bibr17-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132306"},{"key":"bibr18-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"bibr19-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000405"},{"key":"bibr20-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.017"},{"key":"bibr21-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10123"},{"key":"bibr22-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200106000-00002"},{"key":"bibr23-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"bibr24-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"bibr25-0271678X18783628","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.184481"}],"container-title":["Journal 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