{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:58:46Z","timestamp":1777795126160,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Patients with asymptomatic, high-grade internal carotid artery stenosis often suffer from subtle cognitive impairments with unclear underlying neuro-cognitive mechanisms. Thus, we hypothesized that stenosis-related unilateral cerebral hypoperfusion leads to an ipsilateral attentional bias; 22 patients with asymptomatic, one-sided high-grade carotid stenosis and 24 age-matched healthy controls underwent pseudo-continuous arterial spin labeling to assess brain perfusion in the territory of the carotid arteries. Furthermore, a parametric assessment of attention functions was carried out on the basis of the computational Theory of Visual Attention. Both patients' perfusion and spatial attention were significantly more lateralized than those of healthy controls. Critically, both asymmetry indices were significantly correlated in patients, i.e. the stronger one-sided relative hypoperfusion, the stronger ipsilateral bias of attention. This association was specifically pronounced in parietal cortices and independent of white matter hyperintensities as a surrogate for cerebrovascular brain damage. Results provide evidence for a link between lateralized hypoperfusion and lateralized attentional weighting in asymptomatic, high-grade carotid stenosis. Data suggest that lateralized hypoperfusion with simultaneous spatial attentional bias might serve as a potential therapeutic target in one-sided carotid stenosis.<\/jats:p>","DOI":"10.1177\/0271678x18815790","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T11:10:35Z","timestamp":1543317035000},"page":"314-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The stronger one-sided relative hypoperfusion, the more pronounced ipsilateral spatial attentional bias in patients with asymptomatic carotid stenosis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-2156","authenticated-orcid":false,"given":"Jens","family":"G\u00f6ttler","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Magnetic Resonance Research Center, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-7012","authenticated-orcid":false,"given":"Stephan","family":"Kaczmarz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Magnetic Resonance Research Center, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Nuttall","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Griese","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natan","family":"Napi\u00f3rkowski","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kallmayer","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Wustrow","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-1928","authenticated-orcid":false,"given":"Christine","family":"Preibisch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Clinic for Neurology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Finke","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Hans-Berger-Department of Neurology, Jena University Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sorg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"TUM Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Department of Psychiatry, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"bibr1-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5449-z"},{"key":"bibr2-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000113759.80877.1F"},{"key":"bibr3-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.112.2.291"},{"key":"bibr4-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"bibr5-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00031-7"},{"key":"bibr6-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101968"},{"key":"bibr7-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318295d71a"},{"key":"bibr8-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1159\/000334182"},{"key":"bibr9-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.97.4.523"},{"key":"bibr10-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b7840c"},{"key":"bibr11-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710002850X"},{"key":"bibr12-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00018-6"},{"key":"bibr13-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.711"},{"key":"bibr14-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.5.509"},{"key":"bibr15-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"bibr16-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104108"},{"key":"bibr17-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20556"},{"key":"bibr18-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16683690"},{"key":"bibr19-0271678X18815790","unstructured":"Schmidt P.\n                      Bayesian inference for structured additive regression models for large-scale problems with applications to medical imaging\n                      . PhD thesis, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany, 2017."},{"key":"bibr20-0271678X18815790","volume-title":"Introduction to probability and statistics for engineers and scientists","author":"Ross SM","year":"2000"},{"key":"bibr21-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.128.4.450"},{"key":"bibr22-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmp.2011.08.005"},{"key":"bibr23-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00045-7"},{"key":"bibr24-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1699"},{"key":"bibr25-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1007\/BF01367588"},{"key":"bibr26-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1987.10478551"},{"key":"bibr27-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824365d3"},{"key":"bibr28-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"bibr29-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113731"},{"key":"bibr30-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.09.027"},{"key":"bibr31-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3236"},{"key":"bibr32-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00396-8"},{"key":"bibr33-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.188"},{"key":"bibr34-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21104"},{"key":"bibr35-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00001"},{"key":"bibr36-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02264-6"},{"key":"bibr37-0271678X18815790","author":"Gottler J","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr38-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345015.35520.52"},{"key":"bibr39-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15613526"},{"key":"bibr40-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.08.012"},{"key":"bibr41-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.590786"},{"key":"bibr42-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1589"},{"key":"bibr43-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.10.086"},{"key":"bibr44-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0064-5"},{"key":"bibr45-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0618-4"},{"key":"bibr46-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4798"},{"key":"bibr47-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.515775"},{"key":"bibr48-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.518357"},{"key":"bibr49-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000139"},{"key":"bibr50-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000167"},{"key":"bibr51-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.003390"},{"key":"bibr52-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00028-9"},{"key":"bibr53-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.6.1263"},{"key":"bibr54-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.008"},{"key":"bibr55-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.014"},{"key":"bibr56-0271678X18815790","doi-asserted-by":"publisher","DOI":"10.1177\/197140091302600409"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X18815790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X18815790","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X18815790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:16:05Z","timestamp":1777493765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X18815790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1177\/0271678X18815790"],"URL":"https:\/\/doi.org\/10.1177\/0271678x18815790","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]}}}