{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:29:41Z","timestamp":1790400581116,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Brain collateral circulation is an essential compensatory mechanism in response to acute brain ischemia. To study the temporal evolution of brain macro and microcollateral recruitment and their reciprocal interactions in response to different ischemic conditions, we applied a combination of complementary techniques (T2-weighted magnetic resonance imaging [MRI], time of flight [TOF] angiography [MRA], cerebral blood flow [CBF] imaging and histology) in two different mouse models. Hypoperfusion was either induced by permanent bilateral common carotid artery stenosis (BCCAS) or 60-min transient unilateral middle cerebral artery occlusion (MCAO). In both models, collateralization is a very dynamic phenomenon with a global effect affecting both hemispheres. Patency of ipsilateral posterior communicating artery (PcomA) represents the main variable survival mechanism and the main determinant of stroke lesion volume and recovery in MCAO, whereas the promptness of external carotid artery retrograde flow recruitment together with PcomA patency, critically influence survival, brain ischemic lesion volume and retinopathy in BCCAS mice. Finally, different ischemic gradients shape microcollateral density and size.<\/jats:p>","DOI":"10.1177\/0271678x19827251","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T20:30:57Z","timestamp":1549571457000},"page":"276-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL\/6 mouse models"],"prefix":"10.1177","volume":"40","author":[{"given":"Marco","family":"Foddis","sequence":"first","affiliation":[{"name":"Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Winek","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajetan","family":"Bentele","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health, BIH, Unit Bioinformatics, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, NeuroCure Cluster of Excellence and Charit\u00e9 Core Facility 7T Experimental MRIs, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-3800","authenticated-orcid":false,"given":"Sonja","family":"Blumenau","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Reichhart N","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Experimental Ophthalmology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, 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Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Joussen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Experimental Ophthalmology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Experimental Ophthalmology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Beule","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health, BIH, Unit Bioinformatics, Berlin, 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