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Current interventions for cardiac arrest focus on the reversal of precipitating cardiac pathologies and the implementation of supportive measures with the goal of limiting damage to at-risk tissue. Despite the widespread use of targeted temperature management, there remain no proven approaches to manage reperfusion injury in the period following the return of spontaneous circulation. Recent evidence has implicated the lung as a moderator of systemic inflammation following remote somatic injury in part through effects on innate immune priming. In this review, we explore concepts related to lung-dependent innate immune priming and its potential role in PCAS. Specifically, we propose and investigate the conceptual model of lung\u2013brain coupling drawing from the broader literature connecting tissue damage and acute lung injury with cerebral reperfusion injury. Subsequently, we consider the role that interventions designed to short-circuit lung-dependent immune priming might play in improving patient outcomes following cardiac arrest and possibly other acute neurological injuries.<\/jats:p>","DOI":"10.1177\/0271678x19835552","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T02:05:32Z","timestamp":1552529132000},"page":"939-958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["The post-cardiac arrest syndrome: A case for lung\u2013brain coupling and opportunities for neuroprotection"],"prefix":"10.1177","volume":"39","author":[{"given":"Nguyen","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Neuroscience, School of Medicine and Dentistry, The University of Rochester, Rochester, NY, USA"},{"name":"Center for Neurotherapeutics Discovery, School of Medicine and Dentistry, The University of Rochester, 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