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Growing evidence suggests that in chronic kidney disease patients, ischemic strokes are more common than hemorrhagic strokes. Chronic kidney disease is asymptomatic until an advanced stage, but mild to moderate chronic kidney disease incites various pathogenic mechanisms such as inflammation, oxidative stress, neurohormonal imbalance, formation of uremic toxins and vascular calcification which damage the endothelium and blood vessels. Cognitive dysfunction, dementia, transient infarcts, and white matter lesions are widespread in mild to moderate chronic kidney disease patients. Uremic toxins produced after chronic kidney disease can pass through the blood\u2013brain barrier and mediate cognitive dysfunction and neurodegeneration. Furthermore, chronic kidney disease precipitates vascular risk factors that can lead to atherosclerosis, hypertension, atrial fibrillation, and diabetes. Chronic kidney disease also exacerbates stroke pathogenesis, worsens recovery outcomes, and limits the eligibility of stroke patients to receive available stroke therapeutics. This review highlights the mechanisms involved in the advancement of chronic kidney disease and its possible association with stroke.<\/jats:p>","DOI":"10.1177\/0271678x19866733","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T03:36:21Z","timestamp":1564630581000},"page":"1893-1905","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Chronic kidney disease in the pathogenesis of acute ischemic stroke"],"prefix":"10.1177","volume":"39","author":[{"given":"Bharath","family":"Chelluboina","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7915-2810","authenticated-orcid":false,"given":"Raghu","family":"Vemuganti","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"William S. 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