{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:04:30Z","timestamp":1790816670129,"version":"4.1.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>\n                    Endothelin-1 (ET-1) is a highly potent vasoconstrictor peptide released from vascular endothelium. ET-1 plays a major role in cerebrovascular disorders and likely worsens the outcome of acute ischaemic stroke and aneurismal subarachnoid haemorrhage through vasoconstriction and cerebral blood flow (CBF) reduction. Disorders that increase the risk of stroke, including hypertension, diabetes mellitus, and acute myocardial infarction, are associated with increased plasma levels of ET-1. The in\u00a0vivo human cerebrovascular effects of systemic ET-1 infusion have not previously been investigated. In a two-way crossover, randomized, double-blind design, we used advanced 3 tesla MRI methods to investigate the effects of high-dose intravenous ET-1 on intra- and extracranial artery circumferences, global and regional CBF, and cerebral metabolic rate of oxygen (CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ) in 14 healthy volunteers. Following ET-1 infusion, we observed a 14% increase of mean arterial blood pressure, a 5% decrease of middle cerebral artery (MCA) circumference, but no effects on extracerebral arteries and no effects on CBF or CMRO\n                    <jats:sub>2<\/jats:sub>\n                    . Collectively, the findings indicate MCA constriction secondarily to blood pressure increase and not due to a direct vasoconstrictor effect of ET-1. We suggest that, as opposed to ET-1 in the subarachnoid space, intravascular ET-1 does not exert direct cerebrovascular effects in humans.\n                  <\/jats:p>","DOI":"10.1177\/0271678x19874295","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T21:46:17Z","timestamp":1568065577000},"page":"1685-1694","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Cerebrovascular effects of endothelin-1 investigated using high-resolution magnetic resonance imaging in healthy volunteers"],"prefix":"10.1177","volume":"40","author":[{"given":"Anders","family":"Hougaard","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaira","family":"Younis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrim","family":"Iljazi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-8957","authenticated-orcid":false,"given":"Kristian A","family":"Haanes","sequence":"additional","affiliation":[{"name":"Department of Clinical Experimental Research, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Functional Imaging Unit, Nuclear Medicine and PET, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Functional Imaging Unit, Nuclear Medicine and PET, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal M","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA"},{"name":"Department of Neurosurgery, Yamaguchi University School of Medicine, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars S","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Clinical Experimental Research, Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Biochemistry, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk","family":"Ayata","sequence":"additional","affiliation":[{"name":"Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"bibr1-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"bibr2-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1038\/45809"},{"key":"bibr3-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011833"},{"key":"bibr4-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.7.1014"},{"key":"bibr5-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00059-2"},{"key":"bibr6-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00019"},{"key":"bibr7-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.77.1.0096"},{"key":"bibr8-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.666693"},{"key":"bibr9-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(94)90098-1"},{"key":"bibr10-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959948"},{"key":"bibr11-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.117366"},{"key":"bibr12-0271678X19874295","first-page":"159","volume":"25","author":"Donatelli M","year":"1994","journal-title":"Diabetes Res"},{"key":"bibr13-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.510"},{"key":"bibr14-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80214-1"},{"key":"bibr15-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00219-2"},{"key":"bibr16-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1415"},{"key":"bibr17-0271678X19874295","first-page":"F411","volume":"266","author":"S\u00f8rensen SS","year":"1994","journal-title":"Am J Physiol"},{"key":"bibr18-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr19-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0682-8"},{"key":"bibr20-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-25"},{"key":"bibr21-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2008.2005752"},{"key":"bibr22-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"bibr23-0271678X19874295","first-page":"58","volume":"9","author":"Grabner G","year":"2006","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"bibr24-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"bibr25-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"bibr26-0271678X19874295","first-page":"1595","volume":"2007","author":"Kabir Y","year":"2007","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"bibr27-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(96)00092-6"},{"key":"bibr28-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25442"},{"key":"bibr29-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197607000-00001"},{"key":"bibr30-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.49"},{"key":"bibr31-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.110"},{"key":"bibr32-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17737909"},{"key":"bibr33-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.11.1553"},{"key":"bibr34-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(89)90047-3"},{"key":"bibr35-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90644-O"},{"key":"bibr36-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.12.1276"},{"key":"bibr37-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S56071"},{"key":"bibr38-0271678X19874295","first-page":"1125","volume":"250","author":"Clozel M","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr39-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90956-C"},{"key":"bibr40-0271678X19874295","first-page":"R581","volume":"261","author":"Garc\u00eda JL","year":"1991","journal-title":"Am J Physiol"},{"key":"bibr41-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411431333"},{"key":"bibr42-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f9626a"},{"key":"bibr43-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1113\/JP271884"},{"key":"bibr44-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1113\/JP271981"},{"key":"bibr45-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00006"},{"key":"bibr46-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1672"},{"key":"bibr47-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.10.1860"},{"key":"bibr48-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.666693"},{"key":"bibr49-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.192"},{"key":"bibr50-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf007"},{"key":"bibr51-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00227.2003"},{"key":"bibr52-0271678X19874295","first-page":"204","volume":"232","author":"Dreier JP","year":"2007","journal-title":"Exp Biol Med"},{"key":"bibr53-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2009.009068"},{"key":"bibr54-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02390.x"},{"key":"bibr55-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01739.x"},{"key":"bibr56-0271678X19874295","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411423314"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X19874295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0271678X19874295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0271678X19874295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:16:37Z","timestamp":1777493797000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0271678X19874295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0271678X19874295"],"URL":"https:\/\/doi.org\/10.1177\/0271678x19874295","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}